Larry is starting on a reduced dose tomorrow. He spent three days last week in ICU. Oncologist was out of town and no one could figure out why his temperature kept going up to 104 and he was having seizures. Whether seizures were caused by brain mets or fevers or both we will never know. We know fevers were caused by combo. I know it took a lot out of him. I think I see why everyone on this sight says melanoma specialist. Doctors at our hospital have never heard of the drugs Larry is on. Larry really likes his oncologist. . Financial counselors and social workers are really great dealing with insurance to get the meds here. Doc has said if he can't take the reduced dose there is nothing else they can do for him here. I know the drugs were working because 3 centemeter brain met is now 2 centemers after 18 days on Tafinlar Mek Combo. I hope the reduced dose works for us.