I have been diagnosed with stage IV melanoma with mets on liver / lungs, etc. 8 weeks ago and I am now taking GSK'S combo. The doctor said Ipi was not an option as it is not clear wether I would respond at all and if I did on time to survive. Initial response could take up to 4 months.
Now I am reading that there are patients for whom the combo still works fine after 3 years, for others it stopped working after 5 months. The abarage according to a trial being 10.5 months.
I also understand that after discontinuing the combo about 50% show a rapid progress of their desease, in 50% cancer growth seems to be stopped or very slow.
Now I am kind of worried that I might run into the same problem in a few months again (of course I am praying and hoping for the better outcome) that Ipi may be too slow to help!
I hope they extend compassionate care for PD1 to Europe soon so I have a chance.
Does any of you have any other ideas what could be possible options after BRAF / MEK? I also heard that there are trials of PD1 and / or Ipi together with BRAF / MEK or discontinuing BRAF / MEK rather during a time when it works well and switching to other drugs instead of waiting until the melanoma is already spreading again.
Does any of you have experience with such a situation and knows of any soutions? Is IL-2 still an option?