Questions about lab values with Yervoy treatment

Hi,

I finished my 4th dose of Yervoy 5 days ago. Minimal symptoms with 1st and second dose ( a little itching, occasional diarrhea (prob food related) and a little tired. After 3rd dose started to have some fever and chills just at night on days I was really tired. I also developed some joint pain especially in my left hip ( surgery on right leg) and some in my back. This was severe at times. Also just generalized stiffness like someone with arthritis. I don't know if this is from the IPPI. I was also doing radiation on my right leg at the same time and think the awkward position could have something to do with this. This is better in the last week ( finished rad thx last week), but I still have aching in my hips at night.

Had visit w oncologist with last treatment and he told me my liver enzymes were up. I also found out LDH was up. He also did a panel to check for arthritis due to the pain I was having. This was fine except C reactive protein which was 26-nml cut off is like 10. This is a sign of inflammation in the body. My dr said he wasn't worried about this number, but sounded more concerned about liver enzymes. Of course I scoured the Internet on CRP levels and found this could be a marker of advancing disease in melanoma patients (ugh).

So now of course I'm thinking pain in the bones must be mets. But, the more rational side of me thinks this should all just be related to the Yervoy not to mention the radiation which I know caused a lot of inflammation due to the increased redness in my skin (fortunately not painful except a little irritated in groin area where undies rub).

Has anyone else had LDH and liver enzymes rise during Yervoy treatments? How about CRP levels?

I'll do PET/CT and brain MRI in next 2-3 weeks. This time severe scanxiety.

Julie in Las Vegas