Monosomy 3 Test Validity?

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10/10/2012 8:12pm
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Replies: 2

Saw this in a tweet from @MRFCureOM: http://talkabouthealth.com/can-a-very-large-choroidal-tumor-truly-be-low-risk-if-shown-so-in-monosomy-3-test-result-i-thought-large-usually-meant-high-risk wherein Dr. William Harbour pretty much discounts the genetic test for monosomy 3 in favor of the Class1/2 Castle Biosciences gene expression test.  He says, in part, "I do not trust the monosomy 3 test, so I cannot specifically comment on that aspect of the question. The monosomy 3 test is inferior to the Castle Biosciences test that gives a class 1 or class 2 result. All but 2-3 centers in the US are now using it."

I know the two tests were discussed in the June CURE OM web educational event but my question is, does anyone know what Dr Harbour is basing his  opinion on?  Is there some study that indicates one is a more effective predictor or metastatic OM or is this just a little salesmanship and a case of "not invented here?"

lak - (10/11/2012 - 2:45am)

I am afraid that I am uncomfortable with this bold statement I also would like reassurances that there are no conflicts of interest between Dr Harbour and the company he advertises.

 

Its just such a bold statement that does not seem to be well supported by published papers that I have seen.

If any one can send me a link to a paper comparing the 2 processes i would appreicate this.

 

Lesley

lak - (11/22/2012 - 4:25am)

I think if one watches the first Webinair it explains the situatin about genetic testing in a very unbiased and clear supportive way.