dermal or vascular vaccine therapy for stage 3 B melanoma

Posted By
12/21/2013 7:52am
View other posts by
Activity
Replies: 3

recently i posted that i had refused interferon after being randomized to the interferon arm of the ipi clinical trials.  i feel i made the appropriate decision for myself at this stage of my life.   certainly i am not agaist clinical trials, just against interferon.   does anyone have any information regarding vaccine trials that are either dermal or intravascularly used as an adjuntive therapy for this stage of mel?  i have read about a couple at the university of va.   mayo clinic has a new one.   what has been your experience?  have these  vaccines been successful in any way.   i want to be pro active, and would like to have some therapy rather than watch and wait.     thanks for your knowledge and help.  lucy3

Here's a list of clinical trials within 200 miles of Baltimore.  National Cancer Institue has a good searchable database.

http://www.cancer.gov/clinicaltrials/search/results?protocolsearchid=122...

Hope that helps and good luck.

This link will bring you to a trial I participated in last year.

http://clinicaltrials.gov/ct2/show/NCT01456104

Have you checked Johns Hopkins? They have the following trial going on:

J1112: A FEASIBILITY AND TOXICITY STUDY OF A GM-CSF SECRETING ALLOGENEIC MELANOMA VACCINE (MELANOMA GVAX) ADMINISTERED ALONE OR IN COMBINATION WITH CYCLOPHOSPHAMIDE IN SUBJECTS WITH SURGICALLY RESECTED AT-RISK MELANOMA
This melanoma vaccine trial is a phase I study for patients with stage IIB, IIC, III or IV melanoma who have undergone complete surgical resection but who are at risk for developing recurrence of their disease.  Melanoma GVAX is an investigational vaccine designed to teach the immune system to recognize and eliminate melanoma tumors, which may persist at a microscopic level after surgery.  In this study, some patients will receive Melanoma GVAX alone (low dose or high dose), while others will receive Melanoma GVAX plus low-dose cyclophosphamide. Cyclophosphamide is a chemotherapy frequently used in cancer treatment.  In this study, it will be given at a low dose to try to augment the effects of the vaccine.  The purpose of this study is to find the optimal dose of Melanoma GVAX, with or without cyclophosphamide, that is safe and that produces an immune response.  The vaccine will be given in the skin monthly for four doses.  Eligible patients must be ≥18 years old with melanoma arising in the skin or mucous membranes (such as the nostrils, mouth, or rectum) that has been completely resected at least 2 weeks but no more than 6 months prior to receiving the first treatment on this trial.  Patients with melanomas arising in the eye (ocular) are not eligible.  Participants must not have hepatitis, HIV, or any history of an immune disorder.  Patients must not have received any type of cancer immunotherapy, such as interleukin-2, interferon alfa or other melanoma vaccines.  Patients will be evaluated on this trial for 6 months and then followed yearly for 5 years.

http://www.hopkinsmedicine.org/kimmel_cancer_center/centers/melanoma/clinical_trials/

Stage III, Unknown Primary; 1 positive node in left axilla; currently participating in GSK DERMA (MAGE A3 vaccine) trial