Failed Bio-Chemo Need Advise on PD-1 Antibody Combo

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11/8/2010 11:25am
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Replies: 14

 

I did the 6 rounds of Bio-Chemo things were shrinking well, then went on the maintenance part, did 2 rounds of maintenance then scans showed developed new tumors in the liver. There are multiple new lesions laterally in the liver in segment 8 there are new lesions in segment 5 and 6 as well. Existing tumors were stable or shrinking a little.

Dr. Weber advised I go on the PD-1 Antibody Combo Trial. There will not be any openings until 4 weeks pass, so I am getting worried about waiting so long before I can jump into treatment.

My HLA Type is HLA2 Positive so Dr. Weber said I have good options. Asked if I could go on IPI first so I could get started on something quicker, he said I would not qualify on the PD-1 trial if IPI was first, but could do IPI  if the PD-1 trial did not work.

Moffit sent slides and bloodwork to see what I am compatible with as far as BRAF & Mek inhibitor trials I won't get results for about 3 weeks.

A friend found the MRI Guided Laser Ablation trial and I sent the contact a msg to see if I would qualify http://www.mayoclinic.org/news2010-jax/6006.html

Looking for any comments or advice that I should consider while I wait.

Thanks,

Rocky (Stage IV Liver Mets)

Rocky,

I don't have any words of advice but just wanted to wish you well as you begin your new trial! 

molly

Thanks so much for your kind thoughts.

Rocky

just wanted to drop you a line and say my thoughts are with you.  I learn a lot of from following your posts and wish you the best with the next level of treatment.

pat on long island

Thanks so much Pat. I pray that we will be following each others post for many more years to come.

Rocky

Hi Rocky 

its frustrating waiting for things to start. I read Delcath presented their Liver Perfusion method at ASCO this year with promising results. It isolates the liver from your body so the rest of you does not get a punch. This might slow/stop progression until you start something else.

Look up Delcath.com

 

best wishes

James

Thanks James, I will bring this up to the doctor. I think they do the Delcath system @ Moffit.. but not sure.

Rocky

I hope whatever you end up doing will work for you.  Lord knows you've earned some serious break time from the Beast.

Hang in there Rocky!  You're a tough fighter. 

Love,

Amy

I continue to praise God in this storm, counting my blessings & enjoying my "bonus time!"

Love You Too Amy... Your posting... and that is a wonderful thing.

Rocky

Wishing you the best, Rocky.

Jule

Oh, I have slipped the surly bonds of earth and danced the skies on laughter-silvered wings.........put out my hand and touched the face of God.
John Gillespie Magee, Jr

Hi Rocky,

I read with angst your news......I too learn a lot from your posts plus I admire your steady pace of searching, researching, and keeping optimistic in spite of certain drugs not working. I am keeping my fingers crossed that things will get sorted out very soon, I known none of us like waiting! I am sending positive thoughts and wishes for your melanoma to respond to a treatment soon!

Hugs,

Vermont_Donna

Thanks Donna,

I appreciate the kind thoughts and wishes. We are going to keep moving forward as far as I can go. And keep fighting.

Rocky

Thanks Jule I appreciate the kind words.

Rocky

I'm on the ipi trial, but wish I had done the Anti PD1 trial first.  I've heard very good things about Anti PD 1, and there are fewer side effects than ipi.  

I cannot comment on how waiting 4 weeks will affect you, but I know I had to wait 28 days after chemo before I could begin the ipi trial.  It is possible that you will need to wait to start any trial.  

It is good to know if you are BRAF positive, but I think the probability of a durable response is much higher with antiPD1 than BRAF.  

I hope that things turn out well for you.

Thanks stillhopeful,

I hope your ipi trial does well. I appreciate the advice and will keep it close to my thinking cap when conversations and options begin with the Dr....

Rocky