thanks to Brian for posting this link. Watched the discussion yesterday night together with my wife and we both found it very informative.
There are some questions, however, that I would hope the community could help me get answers to
- in the clip they mention dendritic cell therapy for glioblastoma: i have spoken to one expert here in Austria who suggested that method: As far as I understand the draw some blood, isolate the dendritic cell which are kind of baby immune cells, prime them with your own or generic tumor mateial to give them a picture of their future enemy. They create a vaccine that is then reinjected under you skin over a certain period once a week or so. In my country this is known as experimental method with no evidence, thus not covered by public insurance. The cost as far as I know is about 20 000$.
Q: what is the situation in the US for melanoma? Does any center offer this treatment method? Would this be covered? Does anybody know any evidence on that?
- i heard that TIL has been done successfully by dr. rosenberg at the NIH with rates of 40% full remission in a very small sample of patients. The risks are high as part of the treatment is a chemo that shuts down your immune system.
Q What is the status there? Has this become more widely used? Is this pursued by some research group and improved? If the rate of 40% is correct, why don't we hear more about that?
- dr. Wolchok mentions that the combination of Nivo and Ipi has up to 65% of people treated respond. Where does this number come from? in the same context I had read that the reponse rate to the combination is not higher than the 41% reponse rate to Anti PD1 without Ipi.
- this brings me to the last question: is the definition of full vs. Partial vs. Non responders standardized over all trials but defined in each trial? I think either dr. Wolchok or de. Hodi in a different presentation i saw on youtube said that 20% of pateint who received Ipi had a survival of 3 years? Is this then the same for the 41% or a bit more in PD1?
Thanks in asvance for all the controbutions!