I visit often, and rarely post but would very much appreciate insight and feedback. I am (as of later this morning) an 8 year survivor of stage IV melanoma. Early on I was treated with bio chemo + 2 years of IL2 pulse maintenance and managed to remain disease free until 2009. Since then I have been waging war against a relapse that has once again reared it's ugly head. I have had surgeries and did 10 months of PLX and the question is "now what". My relapse is very localized at this point with one deep lesion, high in my axilla, nearly at my neck level and thus far, my disease has behaved in a fairly slow growing pattern. The lesion is judged to be resectable but tricky and I recently had surgery in that area. Of course the other obvious option is Ipi. The only hiccup with this is that I have had a tremendously difficult time with every systemic treatment thus far (chemo, IL2, PLX). If there is a side effect, it seems to manage to find me and in great proportions and the thought of going down this road again scares the ----out of me. That said, if any of you out there have experiences that were rough with bio chemo/IL2 but have been easier with Ipi, I could REALLY stand to hear from you right now! I am a mom of two (9/10) that has missed the last two summers and we are all in desperate need of a few months with strong mom back in action and able to participate in a long planned and much needed family trip. In my best guess, this will not be the case if Ipi is our choice. Please share any good Ipi experiences you may have and any other insight. Thanks much and be well!