I've heard you don't know if one is respondng to IPI for three months. Buddy had one tumor shrink and the others that were measured increase in size. He's had no side effects, the fatigue was there already due to craniology and WBR--He has numerous tumors - liver, lungs, spleen and the brain mets. Dr. said he is anemic, will have blood transfusion next week. Also, if he has any more imbalance while walking, he will need MRI - said he could get gamma knife and still continue with IPI- do you think they would do a gamma knife to brain mets if he has more than 3? Is there a pill or something for blood - H&H is 11 - going south quickly, will transfuse at 9 - has blood work Sunday. Is there anything to do to prevent a seizure that we are not doing now?