Brent has been on the GSK MEK trial at MD Anderson since Feb 2010. I keep reading about the B raf trials not being durable. He will be scanned on the 16th of this month. This is month 7 for him. He is on the highest dosage for the trial at 2.5 mgs .So far we have overall tumor shrinkage of about 30%. The side effect of the rash is our worse concern. He is now taking antibiotics for the sores. It seems that there is not a lot of info yet on the MEK trial results from GSK. I am trying to closely follow this forum but may have missed the information I am looking for. I do not want to be scrambling to find a combination trial at the last minute, so any information would be helpful. We have specifically asked our oncologist about a plan B and he is dismissive or our question wanting us to wait and cross that bridge if we need to.