path report #1
Ten cross sections of four deifferent lymph nodes are examined on multiple slides. All cross sections are immunostained for HMB45. On one slide only, slide B2, in a subcapsular location four cells exhibit immunoreactivity for HMB45 staining. The cells are not cytologically abnormal. I can't say with certainty they represent malignant melanoma. They could represent nuvus cells within a lymph node.
Sent the slides to Mayo and here is what they said.....
I am writing regarding the material that you sent from RB, a 32-year-old women. These are very interesting and challenging slides. I am in complete agreement with the original diagnosis of malignant melanoma on the right leg. There are occasional mitotic figures present with lision as well as the measured depth of 1.1 mm. Sentinel lymph node is quite interesting. On H&E, there is a clear-cut deposition of melanocystic type cells present within the capsule of the nevus. A few of these cells stain positive for HMB-45, but the vast majority of them do not stain for HMB-45. This is an intersting pattern in that the majority of capsular melanocytic nevi are Melan-A/Mart-1 positive, but these cells as well as their architectural location that these are most consistent with a capsular melanocytic nevus.
My questions are.....
1. they say "nothing to be worried about" but then I heard something about a micro-matasti.....what is that, and should I be worried?
2. I was dx with a 2a, but no ulceration and with it being a depth of 1.1 wouldn't that be a stage1???
Thanks for reading and for those that reply...thanks for that too!