My daughter-in-law was diagnosed with Metastatic Melanoma in January after monthes of headaches and the neurosurgeon was "pretty sure" it was NOT melanoma on the MRI but I had a feeling it was due to my DIL's past history of a melanoma lesion (left abdomen/3 yrs ago) excised and no follow up. The neurosurgeon did brain surgery and removed "as much as she could" and found it was melanoma. Megan started whole head radiation. That has been over for 3 monthes and the tumor is re-growing, quickly. It is already back up to 2.6 cm. What are the latest, most effective treatments for BRAIN mets. She has had 4 rounds of IPI for the one node that was positive but to my inderstanding, most IV therapies won't help the brain tumor. There is SO MUCH INFO out there but none seem specific to her situation. She is 26 yrs old. She is to start HD IL-2 soon, should this be postponed in light of the brain tumor re-growth? Is there a more DIRECT treatment for the brain tumor that should have/could be given/done/injected INTO the tumor DURING brain surgery? Sorry...lots of questions. Just want to help advocate for her. Thank you for ANY advice. If it is helpful, we live in the midwest (Iowa).