MPIP: Melanoma Patients Information Page

The MPIP is the oldest and largest community of people affected by melanoma hosted through the Melanoma Research Foundation. It is designed to provide support and information to caregivers, patients, family and friends. Once you have been touched by melanoma—either as a patient or as a family member or friend of a patient—you become part of a community. It is not a community anyone joins willingly. But if you must be part of this group, you will find no better place to find the tools you need in your journey with this cancer, and the friends who can make that journey more bearable.

The information on the bulletin board is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

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 Tim... in a msg you posted the other day you said the 'tiny window' would be gone with the upgrade.... 

Does that need to be selected someplace?

 

 

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dian's picture
Replies 5
Last reply 7/30/2010 - 1:23am
Replies by: mlittle, dian, DonW, Anonymous, Janner

I don't seem to have a ..well..bottom, to the screen when I open a post..so I can't scroll from left to right, only up and down. So I can't see a whole post. The right side is cut off for me. To read Janis' reply to Charlie down below, I had to actually hit the 'reply to' button, then it showed up above the reply spot.

am I alone in this? does everyone else have a horizontal scroll bar along the bottom of the posts?

dian

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washoegal's picture
Replies 3
Last reply 7/30/2010 - 8:16am
Replies by: kwahlbin, washoegal

what is the order in whish the posts are displayed?  Doesn't make much snese to me.  Also, any way we could see more per page. Like dropping the banner and jst have a back to home button.

Life is too short to be anything but happy. Falling down is a part of life, getting back up is living.

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Tregs and rethinking cancer immunotherapy
Tyler J. Curiel

San Antonio Cancer Institute, University of Texas Health Sciences Center, and Cancer Therapy & Research Center, San Antonio, Texas, USA.
Address correspondence to: Tyler J. Curiel, San Antonio Cancer Institute, University of Texas Health Sciences Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA. Phone: (210) 562-5286; Fax: (210) 562-5292; E-mail: curielt@uthscsa.edu.

Tumors express antigens that should induce immune-mediated rejection, but spontaneous rejection of established tumors is rare. Recent work demonstrates that one reason for the lack of tumor rejection is that tumors actively defeat host immunity. This concept forces us to rethink current approaches to harnessing potent, specific host immunity to battle cancer, most of which are based on the paradigm that inducing more antitumor immune cells alone is therapeutic. However, as I discuss in this Personal Perspective, a newer paradigm predicts that reducing tumor-driven immune suppression will be clinically beneficial. CD4+CD25+ Tregs are one mechanism of tumor-driven immune evasion that provide prototypical targets for testing novel anticancer treatment strategies within the newer paradigm.

Abstract
Introduction

Tumors express antigens that should induce immune-mediated rejection, but spontaneous rejection of established tumors is rare. Recent work demonstrates that one reason for the lack of tumor rejection is that tumors actively defeat host immunity. This concept forces us to rethink current approaches to harnessing potent, specific host immunity to battle cancer, most of which are based on the paradigm that inducing more antitumor immune cells alone is therapeutic. However, as I discuss in this Personal Perspective, a newer paradigm predicts that reducing tumor-driven immune suppression will be clinically beneficial. CD4+CD25+ Tregs are one mechanism of tumor-driven immune evasion that provide prototypical targets for testing novel anticancer treatment strategies within the newer paradigm.

Source:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857250/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857250 - Tregs and rethinking cancer immunotherapy

This paper is one of the better ones for understanding the whole Treg Thing. Ipilimumasb and Interluekin-2  in combination will change the paradigm in novel anticancer treatment strategies as we see it today and may hold the key to durable remissions of melanoma.

Take care

Jimmy B
 

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Lori C's picture
Replies 6
Last reply 7/30/2010 - 4:49pm

Will is one week past his first carboplatin and taxol treatment.  He's also on a Fentanyl patch for pain, the first time his hip pain has been properly addressed.  So far, he's feeling very well - eating fine, (he wants to go out for Italian food for lunch) and actually seems slightly less fatigued than before he began chemo, which is a bit mysterious.   He goes back for round 2 on August 10th. 

At this point, we've been extremely pleased with the care from Dr. Howard Kaufman and the nurses at Rush in Chicago.  Dr. Kaufman, who is a surgeon as well as head of oncology and a melanoma specialist, is not exactly a touchy/feely kind of doc but he's honest, careful, attentive, and obviously a very excellent doctor.  A huge relief.  And the nurses have been wonderful, especially given Will has some special needs and is not always the easiest person to communicate with.

I'm hoping things will be stable for a while, at the very worst, and at best, this will really reduce the tumors.

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joy_'s picture
Replies 3
Last reply 7/30/2010 - 7:49pm
Replies by: MichaelFL, FertilityDoc

Just got my husbands pathology report from his LND today, and I am curious what this means:  "No areas of unequivocal capsular invation were demonstrated."  That sounds like a good thing.  Anyone know what "capsular invasion" is or if that tells us anything important?

Sorry if this is a dumb question or if I'm over-analyzing things.  I just want to understand everything about it that I can.

5 of 28 nodes were positive.  Amelanotic (same as primary 2 years ago) Currently Stage IIIC.  He's on the road to recovery and looking forward to life as an NED-er again!

Tracy

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Nancy's picture
Replies 6
Last reply 7/30/2010 - 11:44pm
Replies by: jag, Nancy, NicOz, Tim--MRF

You could see everything on the old board - who responded and what responce was given by whom by scrolling...

read what you needed or may need later,  helpful info - easy to use..

It may be that I'm too old to learn new tricks, but the old way was much better than this new board...

Is there any - like voting for what the majority wants - regarding the board, or not??

Hopefully, we'll get back to the 'old way' soon..

 

Nancy/Maryland

 

 

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Drew N's picture
Replies 2
Last reply 7/31/2010 - 8:58am
Replies by: akls, Sharon in Reno

I had a bunch of checkups stacked up, but was nervous about "tweaks" near my surgical site. So in the last month I've seen my onco, dermatologist, surgeon, and have had a CT scan and a colonoscopy for good measure. Plus the usual xrays and bloodwork. All negative. Have a few spots on my liver that haven't budged since late 08, but who knows how long they've been there. So that's nothing new since November 08.

My surgeon told me that my tweaks were simply nerves in the area where there'd been cutting. BTW, he (Dr. Gershenwald) defies surgeon stereotypes--truly a great guy to talk to, and from everything I've seen and heard, a darn good cutter.

Gonna keep pounding the curcumin and enjoying each day. Y'all keep the faith.

Drew Nelson

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So when I got on this evening, I noticed that the format was different but after I played around for a while, I liked it!

Everymoment

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Anonymous's picture
Anonymous
Replies 2
Last reply 8/1/2010 - 11:42am
Replies by: ValinMtl, Anonymous

I am trying to get used to the new board format....not too crazy about it as some things are not working. The Expand All option doesn't work and closes  my browser - Explorer 8.0.

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I am beginning to like the new BB but would really like to see a few additions..the ability to click to left of board and go straight back to bulletin board after reading.  Would like to see longer pages...too few reads per the page, hate having to click to the next and then the next...would it be possible to lengthen taking out the info at bottom of page "Learn More"...isn't it up at the top already?  Val

Live Laugh Love Nothing is worth more than this day!

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Just checking to see if anyone has heard how the little girl Kadynce's check up went?  I did check her caringbridge site but there wasn't an update.  Thanks!

You don't know what your future holds but you know who holds your future!

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Anonymous's picture
Anonymous
Replies 7
Last reply 8/1/2010 - 5:47pm

The last two mornings I have been extremely dizzy. Once in the shower. Had to close my eyes and hold onto the shower door. Couldn't even open my eyes or move to sit down on the bench in the shower. This morning, my husband had to help me walk down the hall. I could not walk without his assistance, and even struggled with his help. But once I'm up a while, it seems fine. I mean I've been a little light-headed lately. But these two big episodes are only in the morning. If it was a brain met, wouldn't it give me trouble other times of the day too? I suppose I should call or email my doctor but wanted to run it by you all first. I am diabetic, but my glucose is pretty good and doesn't fluctuate much. After my dad's quadruple by-pass last month, we've all been on a pretty healthy diet.

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ValinMtl's picture
Replies 1
Last reply 8/1/2010 - 9:01pm
Replies by: Alicia15

I am beginning to like the new BB but would really like to see a few additions..the ability to click to left of board and go straight back to bulletin board after reading.  Would like to see longer pages...too few reads per the page, hate having to click to the next and then the next...would it be possible to lengthen taking out the info at bottom of page "Learn More"...isn't it up at the top already?  Val

Live Laugh Love Nothing is worth more than this day!

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d.wood's picture
Replies 7
Last reply 8/1/2010 - 9:41pm

My husband is stage 3 survivor. We celebrated our 40th wedding anniversary by going hiking in the Grand Canyon. Sun protective clothing, SPF 70 sunscreen, hats and sunglasses....3 days and NO sunburns or tans. We had a ball! We never thought we could do such a thing. It is possible. :) There's life after melanoma! Yea!

Psalm 15

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