A kind of lentiginous skin melanoma It is also known as subungual melanoma. Acral lentiginous melanoma is observed on the palms, soles and under the nail. It occurs on non hair-bearing surfaces of the body which may or may not be exposed to sunlight. It is also found on mucous membranes. Unlike other forms of melanoma, acral lentiginous melanoma does not appear to be linked to sun exposure.
The use of chemotherapy or radiotherapy in addition to surgical resection in the treatment of cancer.
Asymmetry of a skin spot; one half does not match the other.
A type common, non-melanoma skin cancer that arises from the basal cells small round cells found in the lower part of the epidermis, the outer layer of the skin.
The removal of cells or tissues for examination under a microscope.
Blood vessel invasion, aka angioinvasion, as well as lymphatic invasion are described as being present or absent. If present it means that the melanoma has invaded the blood or lymph system respectively.
Depth a melanoma lesion extends below the skin surface measured in millimeters
The individual unit that makes up all of the tissues of the body.
Cellular Description (the type of melanoma):
Is treatment of cancer with anticancer drugs.
Depth a melanoma lesion extends below the skin surface based on involved skin layer (the larger the level number the deeper into the tissue it extends)
A type of research study that tests how well new medical treatments or other interventions work in people. May also be called a clinical study.
Pertaining to the skin
A class of substances that are produced by cells of the immune system and can affect the immune response. Cytokines can also be produced in the lab by recombinant DNA technology and given to people to affect immune responses.
The medical specialty concerned with the diagnosis and treatment of skin diseases.
The lower or inner layer of the two main layers of tissue that make up the skin.
The determination of the nature of a case of a disease or the distinguishing of one disease from another.
Atypical moles; moles whose appearance is different from that of common moles. Dysplastic nevi are generally larger than ordinary moles (over 5 mm in diameter) and have irregular and indistinct borders. Their color frequently is not uniform and ranges from pink to dark brown; they are flat or have a flat part.
The upper or outer layer of the two main layers of tissue that make up the skin.
Technique in which a lesion is removed from the skin by cutting out the affected area as well as a portion of normal skin surrounding the lesion. This technique is also used to remove larger lesions.
Technique in which a needle is inserted into the tissue or tumor to aspirate (take out) fluid and cells. This tissue/fluid is smeared onto a slide and is then looked at under a microscope. FNA can be performed in the office or under radiology guidance.
Treatment that alters a gene.
Passive immunization of an individual by administration of preformed antibodies (serum or gamma globulin) actively produced in another individual; by extension, the term has come to include the use of immunopotentiators, replacement of immunocompetent lymphoid tissue (e.g., bone marrow or thymus), etc
In its normal place; confined to the site of origin.
Technique in which a lesion is removed from the skin by cutting out the affected area. This technique is often used to remove larger lesions.
Having the quality of invasiveness. Involving puncture of the skin or insertion of an instrument or foreign material into the body; said of diagnostic techniques
A melanoma that has evolved from a lentigo malignant. They are usually found on chronically sun damaged skin such as the face and the forearms of the elderly. The nomenclature is very confusing to both patients and physicians alike.
Any pathological or traumatic discontinuity of tissue or loss of function of a part.
Any of the small, oval or round bodies, located along the lymphatic vessels, that supply lymphocytes to the bloodstream and remove bacteria and foreign particles from the lymph. Also called lymph gland, lymphoglandula, lymphonodus.
The interconnected system of spaces and vessels between body tissues and organs by which lymph circulates throughout the body.
Involves blockage of the lymph vessels, with a resulting accumulation of lymphatic fluid in the interstitial tissues of the body. The lymphatic system consists of lymph vessels and lymph nodes throughout the body. The lymph vessels collect lymphatic fluid, which consists of protein, water, fats, and wastes from cells. The lymph vessels transport the fluid to the lymph nodes, where waste materials and foreign materials are filtered out from the fluid. The fluid is then returned to the blood. When the vessels are damaged or missing, the lymph fluid cannot move freely throughout the system but accumulates. This accumulation of fluid results in abnormal swelling of the arm(s) or leg(s), and occasionally swelling in other parts of the body.
Tending to become worse and end in death. Having the properties of anaplasia, invasiveness, and metastasis; said of tumors.
The edge or border of the tissue removed in cancer surgery. The margin is “negative” or clean when the pathologist finds no cancer cells at the edge of the tissue, suggesting that all of the cancer has been removed. The margin is “positive” or involved when the pathologist finds cancer cells at edge of the tissue, suggesting that all of the cancer has not been removed.
A doctor who specializes in diagnosing and treating cancer using chemotherapy, hormonal therapy, biological therapy, and targeted therapy. A medical oncologist often is the main health care provider for someone who has cancer. A medical oncologist also gives supportive care and may coordinate treatment given by other specialists.
The substance made by melanocytes that gives color to skin and eyes and that absorbs UV rays
Cells in the skin and eyes that produce the pigment called melanin and that transfers it to surrounding skin cells.
A tumor arising from melanocytes within the skin or other organs; melanoma is often referred to as malignant melanoma.
The term used to describe a secondary cancer, or one that has spread from one area of the body to another.
This term describes the frequency of division within the melanoma. Higher mitotic rates are associated with more rapidly dividing cells, and therefore larger lesions with greater potential for metastasis.
A benign growth on the skin (usually tan, brown, or flesh-colored) that contains a cluster of melanocytes and surrounding supportive tissue.
Develops in the mucous membrane that lines the nose, mouth, esophagus, anus, urinary tract and vagina. Mucosal melanomas are especially difficult to detect because they can easily be mistaken for other, far more common conditions.
A benign growth on the skin, such as a mole.
Is the most aggressive form of melanoma. It grows in vertical direction from the outset and grows very fast (months). Nodular melanoma has no known precursor. It is a small black, or if amelanotic, pink nodule that simply enlarges. The lesions tend to bleed.
The sum of knowledge regarding tumors; the study of tumors.
A nurse who specializes in treating and caring for people who have cancer.
A person with a master's degree in social work who works with cancer patients. The oncology social worker/counselor provides counseling and assistance. Patient Navigators are health care professionals whose primary focus is to assist cancer patients, caregivers, and families in “bridging the gaps” within the health care system and decreasing barriers to care by utilizing resources.
Care that prevents or relieves the symptoms of cancer or other diseases. Palliative care does not alter the course of the disease but can improve the quality of life.
A specialist in pathology; one who interprets and diagnoses the changes caused by disease in tissues and body fluids.
Colored by deposit of pigment.
A surgeon who specializes in reducing scarring or disfigurement that may occur as a result of accidents, birth defects, or treatment for diseases
The original tumor
A forecast of the probable course and outcome of a disorder.
Technique in which a lesion is removed from the skin using a cookie cutter type device. This is used to remove small lesions or to sample a portion of a larger lesion.
The melanoma lesion is described as either having RGP present or absent. If present, RGP indicates that the melanoma is growing horizontally or radially, within a single plane of skin layer.
Treatment of disease by means of ionizing radiation; tissue may be exposed to a beam of radiation, or a radioactive element may be contained in devices (e.g., needles or wire) and inserted directly into the tissues, or it may be introduced into a natural body cavity.
The return of symptoms after a remission.
Regression is described as either being present or absent. If it is present the extent of regression is identified. Regression describes an area within the melanoma where there is absence of melanocytic growth. When regression is present the total size of the melanoma is hard to characterize.
Anything that increases a person’s chance of developing a disease.
Satellite lesions are nodules of tumor/melanoma located more than 0.05 mm from the primary lesion. Satellites are described as being present or absent.
The first lymph node to which cancer is likely to spread from the primary tumor.
Removal and examination of the first lymph node(s) to which cancer cells are likely to spread from a primary tumor.
Technique in which a portion of a lesion is cut off the surface of the skin using a scalpel in most cases. This is often performed by a dermatologist in the office.
A common, non-melanoma skin cancer that begins in squamous cells, which are thin, flat cells that look like fish scales.
Is usually characterized as the most common form of cutaneous melanoma in Caucasians. The average age at diagnosis is in the fifth decade, and it tends to occur on sun-exposed skin, especially on the backs of males and lower limbs of females.
Surgeon is a person who performs surgery
A doctor who performs biopsies and other surgical procedures in cancer patients
Care given to relieve the problems associated with a disease or its treatment.
Swelling, one of the cardinal signs of inflammation; morbid enlargement. Neoplasm, a new growth of tissue in which cell multiplication is uncontrolled and progressive.
TILs describes the patient's immune response to the melanoma. When the pathologist examines the melanoma under the microscope he/she looks for the number of lymphocytes within the lesion. This response, or TILs, is usually described as brisk, non-brisk, or absent, although occasionally it can be described as mild or moderate. TILs indicate the immune system's ability to recognize the melanoma cells as abnormal.
Ulceration is the sloughing of dead tissue. This can sometimes occur in the center of a melanoma lesion. The presence of ulceration may alter the stage classification of a melanoma. Ulceration is thought to reflect rapid tumor growth, leading to the death of cells in the center of the melanoma.
Ultraviolet radiation with wavelengths between 320 and 400 nm, comprising over 99 per cent of that reaching the surface of the earth. It enhances the harmful effects of UVB, is responsible for some photosensitivity reactions, and is used therapeutically in the treatment of various skin disorders.
Ultraviolet radiation with wavelengths between 290 and 320 nm, comprising 1 per cent of that reaching the surface of the earth. It causes sunburn and a number of damaging photochemical changes within cells, including damage to DNA leading to premature aging of the skin, premalignant and malignant changes, and various photosensitivity reactions; it is also used therapeutically in the treatment of skin disorders.
A substance or group of substances meant to cause the immune system to respond to a tumor or to microorganisms, such as bacteria or viruses. A cancer vaccine can help the body recognize and destroy cancer cells or microorganisms.
The melanoma is described as either having VGP present or absent. If present it is an indication that the melanoma is growing vertically or deeper into the tissues.
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