Melanoma News

The palladium complexes [(dppe)Pd(L)2PdCl2], [(dppe)Pd(L)2PtCl2], [(dppp)Pd(L)2PdCl2], [(dppm) Pd(L)2NiCl2], and [(dppm)Pd(L)2SnCl4] 15-19 were prepared. The antiproliferative activity of the newly synthesized complexes as well as their previously prepared analogues 3-14 and 20-26 were screened against a large panel of human cancer cell lines derived from haematological CD4+ human T-cells containing an integrated HTLV-1 genome (MT-4). The complex 12a, b exhibited remarkable antiproliferative activity against MT-4, CD4+ human acute T-lymphoblastic leukemia (CCRF-CEM), human splenic B-lymphoblastoid cells (WIL-2NS), human acute B-lymphoblastic leukemia (CCRF-SB), skin melanoma (SK-MEL-28), and prostate carcinoma (DU145) cell lines (CC50 = 0.5 [mu]M, 0.4 ± 0.05 [mu]M, 0.6 ± 0.05 [mu]M, 0.4 ...

Warning sign for potential anticancer approach One treatment being investigated as an adjuvant for anticancer immunotherapies is the use of molecules that trigger the proteins TLR7 and TLR8. For example, the TLR7 stimulant imiquimod is used for the treatment of skin cancer and metastatic melanoma. However, new research, performed by Isabelle Cremer and colleagues, at INSERM U872, Paris, suggests that such approaches should be developed with caution because stimulation of human lung cancer cells with TLR7 or TLR8 agonists increased tumor cell survival and resistance to chemotherapeutics... (Source: Health News from Medical News Today)

NEW YORK (Reuters Health) - People with Parkinson's disease face an increased risk of the most deadly type of skin cancer, new research confirms. (Source: Reuters: Health)

Conclusions  Melanoma prevalence appears to be higher in patients with PD than in the general population. Despite difficulties in comparing other databases with this study population, the study supports increased melanoma screening in patients with PD. (Source: Archives of Neurology)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.