Melanoma News

Advanced Malignant Melanoma: Immunologic and Multimodal Therapeutic Strategies

Immunologic treatment strategies are established in malignant
melanoma treatment, mainly focusing on Interleukin-2 in advanced disease
and interferon alpha in the adjuvant situation. In advanced
disease, therapies with IL-2, interferon and different
chemotherapeutic agents were not associated with better patient
survival in the vast majority of patients. Therefore, an overview
of novel immunological agents and combined therapeutic approaches
is presented in this review, covering allogenic and autologous
vaccine strategies, dendritic cell vaccination, strategies for
adoptive immunotherapy and T cell receptor gene transfer,
treatment with cytokines and monoclonal antibodies against the
CTLA-4 antigen. As emerging treatment strategies are based on
individual molecular and immunological charac...MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

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Complications of ambulatory major dermatological surgery in patients older than 85 years

Conclusions No intra or post-surgical mortality or life-threatening local complications were detected. Most post-surgical local complications appeared after wide excisions and complex reconstruction techniques that prolonged the length of the surgery. (Source: Journal of the European Academy of Dermatology and Venereology)

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Platinum and Palladium-triazole Complexes as Highly Potential Antitumor Agents

The palladium complexes [(dppe)Pd(L)2PdCl2], [(dppe)Pd(L)2PtCl2], [(dppp)Pd(L)2PdCl2], [(dppm) Pd(L)2NiCl2], and [(dppm)Pd(L)2SnCl4] 15-19 were prepared. The antiproliferative activity of the newly synthesized complexes as well as their previously prepared analogues 3-14 and 20-26 were screened against a large panel of human cancer cell lines derived from haematological CD4+ human T-cells containing an integrated HTLV-1 genome (MT-4). The complex 12a, b exhibited remarkable antiproliferative activity against MT-4, CD4+ human acute T-lymphoblastic leukemia (CCRF-CEM), human splenic B-lymphoblastoid cells (WIL-2NS), human acute B-lymphoblastic leukemia (CCRF-SB), skin melanoma (SK-MEL-28), and prostate carcinoma (DU145) cell lines (CC50 = 0.5 [mu]M, 0.4 ± 0.05 [mu]M, 0.6 ± 0.05 [mu]M, 0.4 ...

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News From The Journal Of Clinical Investigation: March 8, 2010

Warning sign for potential anticancer approach One treatment being investigated as an adjuvant for anticancer immunotherapies is the use of molecules that trigger the proteins TLR7 and TLR8. For example, the TLR7 stimulant imiquimod is used for the treatment of skin cancer and metastatic melanoma... (Source: Immune System / Vaccines News From Medical News Today)

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News From The Journal Of Clinical Investigation: March 8, 2010

Warning sign for potential anticancer approach One treatment being investigated as an adjuvant for anticancer immunotherapies is the use of molecules that trigger the proteins TLR7 and TLR8. For example, the TLR7 stimulant imiquimod is used for the treatment of skin cancer and metastatic melanoma. However, new research, performed by Isabelle Cremer and colleagues, at INSERM U872, Paris, suggests that such approaches should be developed with caution because stimulation of human lung cancer cells with TLR7 or TLR8 agonists increased tumor cell survival and resistance to chemotherapeutics... (Source: Health News from Medical News Today)

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Melanoma Cases on the Rise

While some researchers suggest the rising rates of melanoma may simply reflect a change in how doctors diagnose melanoma and the increased availability of skin cancer screenings, a leading dermatologist says the increase is real. (Source: WebMD Health)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

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Melanoma risk higher in Parkinson's patients

NEW YORK (Reuters Health) - People with Parkinson's disease face an increased risk of the most deadly type of skin cancer, new research confirms. (Source: Reuters: Health)

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Melanoma Risk Higher in Parkinson's Patients

People with Parkinson's disease face an increased risk of the most deadly type of skin cancer, new research confirms.Source: Reuters Health
Related MedlinePlus Pages: Melanoma, Parkinson's Disease (Source: MedlinePlus Health News)

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Increased Melanoma Risk in Parkinson Disease: A Prospective Clinicopathological Study [Original Contribution]

Conclusions  Melanoma prevalence appears to be higher in patients with PD than in the general population. Despite difficulties in comparing other databases with this study population, the study supports increased melanoma screening in patients with PD. (Source: Archives of Neurology)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

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Socioeconomic Status and Choroidal Melanoma in Scotland [Research Letters]

(Source: Archives of Opthalmology)

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