My husband has been on the combo for 4 months now. Since Feb, he has had 3 rounds of radiation (WBR, spine & now his hip). Recent scan showed improvement in all soft tissues tumors but increased activities in the bone. We are waiting for the approval for Xvega to strengthen the bones. We were told that he is considered very advanced in stage 4, since he has "innumerable" tumors throughout his body. My question is, has anyone had success with treatments being so far advanced in stage 4?