Dabrafenib and Trametinib

Posted By
williez
9/13/2017 7:44pm
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Replies: 7

Hello all, my name is Guillermo and live in Argentina.

I am Stage IV and I am taking Dabrafenib and Trametinib after failing Ipilimumab and Pembrolizumab (after 22 dosis)

Is someone in the group on dabrafenib and trametinib

Thank you for you attention,

Guillermo

Willie

sgreenberg - (9/14/2017 - 1:54am)

Welcome, and I hope this new combo works for you. My wife (and probably half the people in this forum) have experince with Dabrafenib and Trametinib. What's the question?

 

Steven

jahendry12 - (9/14/2017 - 1:01pm)

My  husband is currently on this combo.  How can we help?

Anonymous - (9/15/2017 - 1:32am)

Look into intermittent dosing (2 weeks on, 1 off) -- it seems to delay onset of tumor resistance to the drugs. -- I didn't do this. My response only lasted a few months and I'm kicking myself every day for it!

dmarie - (9/17/2017 - 11:46pm)

Thank you for posting. Is there information about intermittent dosing versus continuous? My husband is starting this drug combo next week, and no one has suggested anything other than continuous. I would greatly appreciate any information you might have. And I hope you are doing okay...

Diane

Anonymous - (9/18/2017 - 1:19am)

This should not be done without consulting the oncologist first. There aren't any studies showing whether this would affect how well the drugs work and sticking with dosing as prescribed is the best way to get the most from the drugs. If side effects become too much, then asking about intermittent dosing or breaks from the drugs would be a reasonable discussion.

dmarie - (9/17/2017 - 11:46pm)

Thank you for posting. Is there information about intermittent dosing versus continuous? My husband is starting this drug combo next week, and no one has suggested anything other than continuous. I would greatly appreciate any information you might have. And I hope you are doing okay...

Diane

Bubbles - (9/21/2017 - 11:48am)

To all...yes!  We know for CERTAIN that  BRAF inhibitors should always be given with a MEK inhibitor along with an intermittent dosing schedule so that side effects AND resistance are decreased.  It is so well accepted and basically the standard of care that it is no longer a point of study...just accepted as the way to manage BRAF inhibitors.  However, here are some older reports when current melanoma treatments were young:

http://chaoticallypreciselifeloveandmelanoma.blogspot.co.uk/2013/01/better-ways-to-use-braf-inhibitors-for.html  

http://chaoticallypreciselifeloveandmelanoma.blogspot.co.uk/2016/11/brafmek-combined-with-immunotherapy.html  

This last link includes:  "BRAF inhibitors combined with MEK inhibitors improved things further with decreased side effects and increased PFS, amounting to 11-12 months depending on the combo.  It also reviews the importance of intermittent dosing as opposed to continuous therapy with BRAFi in order to delay resistance."  

Hope this helps.  Celeste