Salvage Radiosurgery for Brain Metastases:

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12/19/2013 8:15am
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Salvage Radiosurgery for Brain Metastases: Prognostic Factors to Consider in Patient Selection

Stereotactic radiosurgery (SRS) is offered to patients for recurrent brain metastases after prior brain radiation therapy (RT), but few studies have evaluated the efficacy of salvage SRS or factors to consider in selecting patients for this treatment. This study reports overall survival (OS), intracranial progression-free survival (PFS), and local control (LC) after salvage SRS, and factors associated with outcomes.

Methods and Materials

This is a retrospective review of patients treated from 2009 to 2011 with salvage SRS after prior brain RT for brain metastases. Survival from salvage SRS and from initial brain metastases diagnosis (IBMD) was calculated. Univariate and multivariable (MVA) analyses included age, performance status, recursive partitioning analysis (RPA) class, extracranial disease control, and time from initial RT to salvage SRS.


There were 106 patients included in the analysis with a median age of 56.9 years (range 32.5-82 years). A median of 2 metastases were treated per patient (range, 1-12) with a median dose of 21 Gy (range, 12-24) prescribed to the 50% isodose. With a median follow-up of 10.5 months (range, 0.1-68.2), LC was 82.8%, 60.1%, and 46.8% at 6 months, 1 year, and 3 years, respectively. Median PFS was 6.2 months (95% confidence interval [CI] = 4.9-7.6). Median OS was 11.7 months (95% CI = 8.1-13) from salvage SRS, and 22.1 months from IBMD (95% CI = 18.4-26.8). On MVA, age (P=.01; hazard ratio [HR] = 1.04; 95% CI = 1.01-1.07), extracranial disease control (P=.004; HR = 0.46; 95% CI = 0.27-0.78), and interval from initial RT to salvage SRS of at least 265 days (P=.001; HR = 2.46; 95% CI = 1.47-4.09) were predictive of OS.


This study demonstrates that patients can have durable local control and survival after salvage SRS for recurrent brain metastases. In particular, younger patients with controlled extracranial disease and a durable response to initial brain RT are likely to benefit from salvage SRS.

I'm me, not a statistic. Praying to not be one for years yet.

Thank you Jerry for keeping up with the literature!


Yes, thanks Jerry. As a science geek, I get frustrated when I can not read the full length article-- abstracts don't usually have enough detail for me properly evaluate the data. However, working with what we have...

This article says that IF one's melanoma responds well to whole brain radiation (WBR) and IF there is little disease progression in the rest of the body (presumably through some type of treatment) then SRS of a few new brain mets can significantly lengthen one's lifespan.

I think we all assumed that, but it's nice to know that it is official.  

I hate abstracts and summaries too.  Wish I could afford to Officially jooin the full article world.  Have seen many questionson different pllaces by new people asking about  SRS and WBR.  Several people have been directed to WBR as the initial seffort when they have anly had a few known brain tumors.  For myself, WBR would be much more of a last resort than a beginning aaction.

I'm me, not a statistic. Praying to not be one for years yet.