Where to go from here??

Posted By
5/17/2017 1:12pm
Replies: 2

Quick background, diagnosed stage 4 in 2014 unknown primary.  Braf neg.  Have done IL-2, Yerovy, Nivolumab, genetic trial of palbociclib and most recently trial of glembatumuab & varlilumab.  Was considered stable on recent trial until two weeks ago when scans showed small brain tumor. Now I'm disqualified for the trial.   Will have sterotactic surgery tomorrow to treat the brain tumor. My question is now that I have the brain tumor, will I qualify for any trials, and if not what is next plan of action?  Thanks for any input.

Bubbles - (5/17/2017 - 2:08pm)

So sorry for all your are dealing with.  Thankfully, once a brain tumor is treated and declared stable (time frame for that varies) most trials will allow participation. (They didn't used to!!  But, most do now.)  You will just have to look at the exclusion criteria of trials you are interested in.  It seems to me  an IDO inhibitor  (like epacadostat) combined with anti-PD-1 might be an option???

Here's one report:  http://www.medpagetoday.com/reading-room/asco/59632

Here is a post I put together a bit ago for some dear ones who had already endured many treatments and still needed options:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/12/trials-for-joshie-and-paulster-and.html  

You will have to look at the clinicaltrials.gov site to see what inclusions/exclusions are and status of the trials at the moment.

Hang in there. Many smart folks will look for more options I am sure!  Get your SRS.  Don't forget to breathe.  We will keep looking...you keep asking.  Wishing you my best.  Celeste

Anonymous - (5/17/2017 - 2:52pm)

Thank you for your info! I will keep fighting!!