I was wondering if anyone could share their experience with Zelboraf. In particular, I would like anyone's insight/experience with foot calluses and related pain. My mom was diagnosed with metastatic melanoma last May. Since then, she has undergone a lung resection, biochemotherapy, and most recently three craniotomies in three months' time. Currently, mom has six brain tumors, a lesion in her liver and also disease in a lymph node near her pancreas. Two and a half weeks ago, mom's oncologist at MDAnderson here in Houston started her on Zelboraf. Since then, she quickly experienced side effects--notably sun sensitivity, a terrible rash all over her body and unbearably painful yellow calluses on the bottoms of her feet. Her oncologist decided to suspend treatment for a week because mom's rash was so terrible and foot pain intolerable, and we will re-visit everything on Monday. I was curious whether others have had the same experience as my mom regarding the excruciating foot pain and if so, how long does it last? What remedies were used to releive the pain? Also, any other contributions regarding your experience with the drug would be most appreciated.