MPIP: Melanoma Patients Information Page

The MPIP is the oldest and largest community of people affected by melanoma hosted through the Melanoma Research Foundation. It is designed to provide support and information to caregivers, patients, family and friends. Once you have been touched by melanoma—either as a patient or as a family member or friend of a patient—you become part of a community. It is not a community anyone joins willingly. But if you must be part of this group, you will find no better place to find the tools you need in your journey with this cancer, and the friends who can make that journey more bearable.

The information on the bulletin board is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

Expand/ Collapse Topic
 
Replies By
View Topic

 Tim... in a msg you posted the other day you said the 'tiny window' would be gone with the upgrade.... 

Does that need to be selected someplace?

 

 

Login or register to post replies.

dian's picture
Replies 5
Last reply 7/30/2010 - 1:23am
Replies by: mlittle, dian, DonW, Anonymous, Janner

I don't seem to have a ..well..bottom, to the screen when I open a post..so I can't scroll from left to right, only up and down. So I can't see a whole post. The right side is cut off for me. To read Janis' reply to Charlie down below, I had to actually hit the 'reply to' button, then it showed up above the reply spot.

am I alone in this? does everyone else have a horizontal scroll bar along the bottom of the posts?

dian

Login or register to post replies.

washoegal's picture
Replies 3
Last reply 7/30/2010 - 8:16am
Replies by: kwahlbin, washoegal

what is the order in whish the posts are displayed?  Doesn't make much snese to me.  Also, any way we could see more per page. Like dropping the banner and jst have a back to home button.

Life is too short to be anything but happy. Falling down is a part of life, getting back up is living.

Login or register to post replies.

Tregs and rethinking cancer immunotherapy
Tyler J. Curiel

San Antonio Cancer Institute, University of Texas Health Sciences Center, and Cancer Therapy & Research Center, San Antonio, Texas, USA.
Address correspondence to: Tyler J. Curiel, San Antonio Cancer Institute, University of Texas Health Sciences Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA. Phone: (210) 562-5286; Fax: (210) 562-5292; E-mail: curielt@uthscsa.edu.

Tumors express antigens that should induce immune-mediated rejection, but spontaneous rejection of established tumors is rare. Recent work demonstrates that one reason for the lack of tumor rejection is that tumors actively defeat host immunity. This concept forces us to rethink current approaches to harnessing potent, specific host immunity to battle cancer, most of which are based on the paradigm that inducing more antitumor immune cells alone is therapeutic. However, as I discuss in this Personal Perspective, a newer paradigm predicts that reducing tumor-driven immune suppression will be clinically beneficial. CD4+CD25+ Tregs are one mechanism of tumor-driven immune evasion that provide prototypical targets for testing novel anticancer treatment strategies within the newer paradigm.

Abstract
Introduction

Tumors express antigens that should induce immune-mediated rejection, but spontaneous rejection of established tumors is rare. Recent work demonstrates that one reason for the lack of tumor rejection is that tumors actively defeat host immunity. This concept forces us to rethink current approaches to harnessing potent, specific host immunity to battle cancer, most of which are based on the paradigm that inducing more antitumor immune cells alone is therapeutic. However, as I discuss in this Personal Perspective, a newer paradigm predicts that reducing tumor-driven immune suppression will be clinically beneficial. CD4+CD25+ Tregs are one mechanism of tumor-driven immune evasion that provide prototypical targets for testing novel anticancer treatment strategies within the newer paradigm.

Source:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857250/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857250 - Tregs and rethinking cancer immunotherapy

This paper is one of the better ones for understanding the whole Treg Thing. Ipilimumasb and Interluekin-2  in combination will change the paradigm in novel anticancer treatment strategies as we see it today and may hold the key to durable remissions of melanoma.

Take care

Jimmy B
 

Login or register to post replies.

joy_'s picture
Replies 3
Last reply 7/30/2010 - 7:49pm
Replies by: MichaelFL, FertilityDoc

Just got my husbands pathology report from his LND today, and I am curious what this means:  "No areas of unequivocal capsular invation were demonstrated."  That sounds like a good thing.  Anyone know what "capsular invasion" is or if that tells us anything important?

Sorry if this is a dumb question or if I'm over-analyzing things.  I just want to understand everything about it that I can.

5 of 28 nodes were positive.  Amelanotic (same as primary 2 years ago) Currently Stage IIIC.  He's on the road to recovery and looking forward to life as an NED-er again!

Tracy

Login or register to post replies.

Nancy's picture
Replies 6
Last reply 7/30/2010 - 11:44pm
Replies by: jag, Nancy, NicOz, Tim--MRF

You could see everything on the old board - who responded and what responce was given by whom by scrolling...

read what you needed or may need later,  helpful info - easy to use..

It may be that I'm too old to learn new tricks, but the old way was much better than this new board...

Is there any - like voting for what the majority wants - regarding the board, or not??

Hopefully, we'll get back to the 'old way' soon..

 

Nancy/Maryland

 

 

Login or register to post replies.

Drew N's picture
Replies 2
Last reply 7/31/2010 - 8:58am
Replies by: akls, Sharon in Reno

I had a bunch of checkups stacked up, but was nervous about "tweaks" near my surgical site. So in the last month I've seen my onco, dermatologist, surgeon, and have had a CT scan and a colonoscopy for good measure. Plus the usual xrays and bloodwork. All negative. Have a few spots on my liver that haven't budged since late 08, but who knows how long they've been there. So that's nothing new since November 08.

My surgeon told me that my tweaks were simply nerves in the area where there'd been cutting. BTW, he (Dr. Gershenwald) defies surgeon stereotypes--truly a great guy to talk to, and from everything I've seen and heard, a darn good cutter.

Gonna keep pounding the curcumin and enjoying each day. Y'all keep the faith.

Drew Nelson

Login or register to post replies.

So when I got on this evening, I noticed that the format was different but after I played around for a while, I liked it!

Everymoment

Login or register to post replies.

Anonymous's picture
Anonymous
Replies 2
Last reply 8/1/2010 - 11:42am
Replies by: ValinMtl, Anonymous

I am trying to get used to the new board format....not too crazy about it as some things are not working. The Expand All option doesn't work and closes  my browser - Explorer 8.0.

Login or register to post replies.

I am beginning to like the new BB but would really like to see a few additions..the ability to click to left of board and go straight back to bulletin board after reading.  Would like to see longer pages...too few reads per the page, hate having to click to the next and then the next...would it be possible to lengthen taking out the info at bottom of page "Learn More"...isn't it up at the top already?  Val

Live Laugh Love Nothing is worth more than this day!

Login or register to post replies.

Just checking to see if anyone has heard how the little girl Kadynce's check up went?  I did check her caringbridge site but there wasn't an update.  Thanks!

You don't know what your future holds but you know who holds your future!

Login or register to post replies.

Anonymous's picture
Anonymous
Replies 7
Last reply 8/1/2010 - 5:47pm

The last two mornings I have been extremely dizzy. Once in the shower. Had to close my eyes and hold onto the shower door. Couldn't even open my eyes or move to sit down on the bench in the shower. This morning, my husband had to help me walk down the hall. I could not walk without his assistance, and even struggled with his help. But once I'm up a while, it seems fine. I mean I've been a little light-headed lately. But these two big episodes are only in the morning. If it was a brain met, wouldn't it give me trouble other times of the day too? I suppose I should call or email my doctor but wanted to run it by you all first. I am diabetic, but my glucose is pretty good and doesn't fluctuate much. After my dad's quadruple by-pass last month, we've all been on a pretty healthy diet.

Login or register to post replies.

ValinMtl's picture
Replies 1
Last reply 8/1/2010 - 9:01pm
Replies by: Alicia15

I am beginning to like the new BB but would really like to see a few additions..the ability to click to left of board and go straight back to bulletin board after reading.  Would like to see longer pages...too few reads per the page, hate having to click to the next and then the next...would it be possible to lengthen taking out the info at bottom of page "Learn More"...isn't it up at the top already?  Val

Live Laugh Love Nothing is worth more than this day!

Login or register to post replies.

d.wood's picture
Replies 7
Last reply 8/1/2010 - 9:41pm

My husband is stage 3 survivor. We celebrated our 40th wedding anniversary by going hiking in the Grand Canyon. Sun protective clothing, SPF 70 sunscreen, hats and sunglasses....3 days and NO sunburns or tans. We had a ball! We never thought we could do such a thing. It is possible. :) There's life after melanoma! Yea!

Psalm 15

Login or register to post replies.

Jim in Denver's picture
Replies 7
Last reply 8/1/2010 - 11:23pm

 I have been meaning to post, but have had a busy July with family.  I have not posted since late May, I think.  I have waited until I have news to report, so here it is!

As background, I was diagnosed in March this yearas Stage IV with lung mets, no primary identified then or since.  Tested negative for BRAFe, k, and g. Limited treatment options locally, so went to MD Anderson almost 3 weeks ago for 3 days,  My Onc there is Dr. Wen Jen Hwu.  I am extremely impressed with MDA - a large operation, but very personal and caring.  Scans showed barely measurable growth in lung mets, since they are barely measurable in the first place (.5 cm).  Dr. Hwu said the mets may not have grown at all over the 3 months since the first scan.  MRI of brain also negative.  She offered me the opportunity to enroll in the Ipi/Temador Trial at MDA, which I gratefully accepted.  She answered all my questions over about an hour about the trial, and I spent around another hour with her our first appointment.  Had a small tumor removed from my left shoulder that appeared about 8 weeks ago, but Dr. Ross left another on on my left thigh to use for measuring possible progress from treatment.

So Tuesday I will travel to Houston with my wife for two days to begin treatment.  The Ipi part is "high dose" - 10mg/kg.  The Temodar is oral chemotherapy taken over 4 days of each 3 week cycle.  The treatments are scheduled for every 3 weeks for 4 cycles, or a total of 3 months.  Scans are done at 6 and 12 weeks.  Maintainence can occur indefinitely if there is a benefit to the initial treatment, on a reduced frequency schedule.  Current research on Ipi is focused on using it in combination with other therapies that have shown effectiveness.  The idea is that there should be at least an "arithmetic" benefit to such a combination (i.e. 1+1=2) but possibly "geometric" benefit (e.g 1+1=3).  This is the purpose of this study.  High dose Ipi has more side effects than the lower dose (3mg/kg - available in the Compassionate Use Study), but also higher efficacy.  The side effects to both treatments should be manageable, but the list of possible ones is long.  I have read here today and in the past about side effects for each drug seperately, but will post again about how everything is going as we go forward.

My kids are at camp this two weeks, so no family issues with my first treatment.  My wife will be with me for the first treatment, and she has arranged family leave.  Our insurance (though her work) and her benefits are very good, so we are fortunate in that regard. I just spent time with my Mom and my sister and her family during vacation.  I emailed them a couple of weeks before that to let them know about my diagnosis.  They have taken the news pretty well, I think, and now understand that I have a good plan to fight this disease.  My wife and kids are encouraged, as am I, by my initial visit to MDA. I will need to tell friends here very soon since my hair may soon be a slightly different color (white!) and I will be a regular visitor to Houston for the forseeable future.  

So that is my story for the recent past, in a nutshell.  I am encouraged somewhat that the disease has not progressed much, if at all, since initial diagnosis in March.  Although my work with the U of Colorado over 3 months did not yield any results, the time spent there has not harmed me either. MDA will keep my Onc at CU informed by email about significant developments in treatment, and they will be my local backup if needed.

In the meantime, I apologize for not keeping in better touch with those of you who have become friends and correspondents through this Board.  You have helped me sustain a positive attitude and sense of humor about this disease, as well as helped with information.  I will write when I can, but may resort primarily to posting here, depending on my energy level this week.  Thank you all for your support, good wishes, and prayers - they have helped us more than you can know.

 

Many Thanks,

Jim in Denver

 

 

 

 

 

Login or register to post replies.

Pages