MPIP: Melanoma Patients Information Page

The MPIP is the oldest and largest community of people affected by melanoma hosted through the Melanoma Research Foundation. It is designed to provide support and information to caregivers, patients, family and friends. Once you have been touched by melanoma—either as a patient or as a family member or friend of a patient—you become part of a community. It is not a community anyone joins willingly. But if you must be part of this group, you will find no better place to find the tools you need in your journey with this cancer, and the friends who can make that journey more bearable.

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LynnLuc's picture
Replies 4
Last reply 1/11/2013 - 12:23pm

 

Not too much new to update today.  Mom has responded slightly to the DEX, and has been able to get a word or two out.  However, there are no other encouraging signs.  Her IV was removed last night and they were not able to re-insert it.  All medications are now being given through shots.  Tomorrow morning will be her last shot of DEX and she will be moved to a local hospice house after that.  While she does seem to be in pain, she is handling it better than you would think.  She always has been a fighter...  I would expect nothing else.  
 
Advocate for your own treatment.. Stage 4 Melanoma NED Surgery,Radiation, Temodar 300Mg July 2009-March 2010, then Thorocotomy...now "Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy"

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Marcia1's picture
Replies 4
Last reply 1/13/2013 - 5:31pm
Replies by: Marcia1, meeshka6059, Janner

Has anyone had experience of an elder person taking Yervoy?  My mother had been taking Temador but her lung melanoma continued to grow so they stopped they.  She did tolerate the Temador fairly well.  I was just concerned with side effects as she was diagnosed last February with Stage IV Melanoma and hasn't really experienced any problems yet.  Thank you.

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Has anyone had experience of an elder person taking Yervoy?  My mother had been taking Temador but her lung melanoma continued to grow so they stopped they.  She did tolerate the Temador fairly well.  I was just concerned with side effects as she was diagnosed last February with Stage IV Melanoma and hasn't really experienced any problems yet.  Thank you.

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Live 4 today. Thank God for all he has done for us. Looking forward to enjoying tomorrow.

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Another article  on Zelboraf

 

In a new study published today in Nature, researchers using a mouse model of melanoma were able to prevent resistance to vemurafenib by altering the dosing schedule from a continuous daily dose to an intermittent dose, suggesting a possible way to prolong the onset of resistance for melanoma patients.

Micrograph of pigmented malignant melanoma; source: Nephron, Wikimedia Commons

Vemurafenib (Zelboraf), a small-molecule kinase inhibitor, is the first targeted therapy approved by the US Food and Drug Administration for metastatic melanoma, approved for tumors that express the BRAF V600E gene mutation. Resistance to the drug, however, is problematic, with the vast majority of patients experiencing tumor regrowth several months into treatment.

Martin McMahon, PhD, of the Helen Diller Family Comprehensive Cancer Center at the University of California San Francisco (UCSF), and colleagues at the Novartis Institutes for Biomedical Research in Emeryville, California found mouse models that become resistant to vemurafenib with chronic exposure have a continued dependency on the BRAF-MEK-ERK signaling pathway. The vemurafenib-resistant tumor growth that develops is actually dependent on the drug. When the drug administration was stopped, tumor regression was observed within 10 days, followed by tumor regrowth. “These data support the hypothesis that vemurafenib-resistant tumors suffer a fitness deficit in the absence of vemurafenib,” the authors conclude.

“Intermittent dosing alternates the selective pressure applied by drug treatment and prevents the evolution of a drug-resistant state,” said Darrin Stuart, PhD, a senior investigator at the Novartis Institutes for Biomedical Research and one of the lead authors of the publication.

The resistance mechanism detected was upregulation of BRAF rather than mutations within BRAF or other genes in the signaling pathway.

“Even cancer cells are sensitive to the level of oncogenic pathway activation such that too little or too much of a pathway to which a cancer cell is addicted can be deleterious to the cell. This phenomenon is known as the ‘Goldilocks effect’,” explained McMahon.

The results may have major implications for the way targeted therapies against active protein kinases are administered. “The current paradigm for oncoprotein kinase directed therapy is continuous administration—this data hints that continuous therapy may not always be the best approach,” said McMahon.

The problem is not an easy fix—physicians need to balance maximal tumor regression, typically achieved by continuous treatment, and delaying the onset of resistance, which this study suggests might best achieved with an intermittent drug dose.

Mice given vemurafenib continuously on a daily basis developed resistance within 100 days of treatment initiation. In contrast, those mice treated for their melanoma intermittently with a 4 weeks on, 2 weeks off regimen did not develop resistance by day 200 of treatment.

It is not yet possible to identify patients whose tumors are dependent on chronic vemurafenib exposure, said McMahon, but “devising such a test is feasible and ongoing.”

“There is evidence that patients with drug-resistant disease experience tumor regression when dosing is suspended, however, the therapeutic approach to test would be to use intermittent dosing from the beginning and not wait until resistance emerges,” said Stuart.

McMahon noted that there is considerable interest at the UCSF Melanoma Clinic to test whether an intermittent dose schedule of vemurafenib and other BRAF V600E inhibitors may increase the duration of responses. “The idea is now out in the clinical community and so fair game for anyone to design an appropriate clinical trial,” said McMahon. Still, more laboratory research is warranted to understand how frequently this type of phenomenon occurs and how too much BRAF V600E activity inhibits the proliferation of melanoma cells addicted to BRAF V600E signaling, said McMahon.

It is possible that changing the dosing schedule of other oral kinase inhibitors could also delay drug resistance in many other tumor types but much more research, both clinical and laboratory, is necessary.

Multiple clinical trials to test alternative dosing regimens of BRAF and likely other targeted, oral inhibitors are expected over the next few years according to Stuart. Exploring rational drug combinations is another approach that Novartis is taking.

The current study is a public–private sector collaboration between UCSF and the Novartis Institute for Biomedical Research with “a free-flow of information between the two groups as well as open sharing of materials and reagent,” said McMahon. McMahon added that testing the effects of intermittent doses of BRAF inhibitors would likely also be part of such a public–private sector partnership.

 

http://www.cancernetwork.com/melanoma-skin-cancer/content/article/10165/...

Advocate for your own treatment.. Stage 4 Melanoma NED Surgery,Radiation, Temodar 300Mg July 2009-March 2010, then Thorocotomy...now "Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy"

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LynnLuc's picture
Replies 9
Last reply 1/15/2013 - 6:19pm
Replies by: JakeinNY, Anonymous, awillett1991, lou2
Advocate for your own treatment.. Stage 4 Melanoma NED Surgery,Radiation, Temodar 300Mg July 2009-March 2010, then Thorocotomy...now "Phase I Study of Anti-PD-1 Human Monoclonal Antibody MDX-1106 and Vaccine Therapy"

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awillett1991's picture
Replies 4
Last reply 1/11/2013 - 6:19pm

Found another article stating how they dosed in the study - 4 weeks on, then 2 weeks off Zel, then repeat. All mice dosed this way were alive at 100 days, all dosed continually were not. Definitely asking my doc about these Swiss mice next wk as he has been talking about dosing me on & off on a schedule. I tolerate Zel so poorly, I think the longest I have ever been on a constant dose was 4-5 weeks since last April anyway.

http://www.bbc.co.uk/news/health-20956179

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mclaus23's picture
Replies 2
Last reply 1/11/2013 - 7:15pm
Replies by: TSchulz, LynnLuc

Hello, my dad concluded with IPI in 10/2011 and has since been showing regression followed by total remission 2 months ago. His scan today showed the 2 tumors in his adrenal glands grew by 1/2 inch and he has one new one on his lymph node near the adreanal gland. He needs to have an MRI asap which hopefullly shows nothing new. If it does not show anything new he is eligible for the PD1 trial. If not it's either IL-2 or IPI again. Has anyone been thru this:????

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Hello, my dad concluded with IPI in 10/2011 and has since been showing regression followed by total remission 2 months ago. His scan today showed the 2 tumors in his adrenal glands grew by 1/2 inch and he has one new one on his lymph node near the adreanal gland. He needs to have an MRI asap which hopefullly shows nothing new. If it does not show anything new he is eligible for the PD1 trial. If not it's either IL-2 or IPI again. Has anyone been thru this:????

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Hello, my dad concluded with IPI in 10/2011 and has since been showing regression followed by total remission 2 months ago. His scan today showed the 2 tumors in his adrenal glands grew by 1/2 inch and he has one new one on his lymph node near the adreanal gland. He needs to have an MRI asap which hopefullly shows nothing new. If it does not show anything new he is eligible for the PD1 trial. If not it's either IL-2 or IPI again. Has anyone been thru this:????

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Hello, my dad concluded with IPI in 10/2011 and has since been showing regression followed by total remission 2 months ago. His scan today showed the 2 tumors in his adrenal glands grew by 1/2 inch and he has one new one on his lymph node near the adreanal gland. He needs to have an MRI asap which hopefullly shows nothing new. If it does not show anything new he is eligible for the PD1 trial. If not it's either IL-2 or IPI again. Has anyone been thru this:????

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Hello, my dad concluded with IPI in 10/2011 and has since been showing regression followed by total remission 2 months ago. His scan today showed the 2 tumors in his adrenal glands grew by 1/2 inch and he has one new one on his lymph node near the adreanal gland. He needs to have an MRI asap which hopefullly shows nothing new. If it does not show anything new he is eligible for the PD1 trial. If not it's either IL-2 or IPI again. Has anyone been thru this:????

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If you TWITTER, there are several Melanoma Research and Foundations accts. on there to follow.   Lots of good info and tweets.   The latest of the latest.

Just sharing......

Nancy (devoted wife of 3 X Warrior Wayne) 

Matt. 15:13 "Every plant that my Heavenly Father hath not planted shall be pulled up by the roots". "With God all things are possible" ! Keep the FAITH !

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