MPIP: Melanoma Patients Information Page

The MPIP is the oldest and largest community of people affected by melanoma hosted through the Melanoma Research Foundation. It is designed to provide support and information to caregivers, patients, family and friends. Once you have been touched by melanoma—either as a patient or as a family member or friend of a patient—you become part of a community. It is not a community anyone joins willingly. But if you must be part of this group, you will find no better place to find the tools you need in your journey with this cancer, and the friends who can make that journey more bearable.

The information on the bulletin board is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

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awillett1991's picture
Replies 7
Last reply 5/23/2013 - 8:21pm

Was wondering about you this morning. I hope all is well.

Amy

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Replies by: NYKaren, Erinmay22, BrianP

My dad is in cycle 2. I would like feedback :)

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Anonymous's picture
Anonymous
Replies 2
Last reply 5/23/2013 - 2:26pm
Replies by: Anonymous, Janner

I had a couple moles removed and told I was lucky that it was pre melanoma but the doctor didn't really explain my path report the first time and I had to have them go in deeper until the margins were clear. I was told that I would have to be vigilant and watched closely could anyone explain to me the path reports?

A. Microscopic examination of the slides show an atypical melanocytic lesion with melanocytes in the epidermis and dermis consistent with a dysplastic junctional nevus. The margins of excision cannot be accessed with certainty.

B. Microscopic examination of the slides show a limited specimen showing atypical proliferation of melanocytes in the dermis with junctional component highly consistent with a junctional dysplastic nevus. Recommended reexcision with negative margins

Final Diagnosis
A. Consistent with a dysplastic junctional nevus The margins cannot be accessed with certainty. Therefore, I recommend re excision with negative margins.

B. dysplastic junctional nevus with positive margins Recommend re excision with negative margins

Here is the path report from re excisions

Sections consist of skin erosion, squamous hyperplasia, edema and mild chronic inflammation. Residual carcinoma or dysplasia is not identified in these sections. The margins are free of dysplasia/carcinoma.

Final Diagnosis
Residual dysplasia is not identified. Erosion, squamous hyperplasia, and mild chronic inflammation.

Can anyone kind of explain to me what all this means in a more understanding way? I am having to see a dermatologist about more suspicious moles that are changing and suspicious on other parts of the body. The two biopsies before from the same leg.

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I just got my pathology report and after cruising this board, I guess it doesn't look too good. Any help or advice would be greatly appreciated.
Superficial spreading amelanotic, Anatomical level : at least iv, greatest thickness at least 2. 9 mm, ulceration present, radial growth phase present, vertical growth phase present epithelioid, spindled, margins extending to the lateral and deep tissue edges , mitosis 16 per sq mm , tumor infiltrating lymphocytes present , non brisk.
But at least there were no micro satellites, lol
Trying to stay positive waiting for the surgeon to call for my appointment . Please help me decipher this

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bikerwifee's picture
Replies 3
Last reply 5/23/2013 - 6:19am
Replies by: BrianP, POW, Swanee

I dont know how but Lynn ldh went down to 900 was 1300. The dr will not be doing the sixth gamma knife. Lynn is to weak. He starts Temador tomo but they gave us only a 15 to 20 percent chance in it working. Theres just nothing else for us to try. Lynn is a fighter and was willing to try this.

Lynn got saved a long time ago and hes says he knows hes going to heaven. I think hes ready but not ready he prayed today and asked God to heal him hes asked God to please take him home if he wasnt going to heal him. Ive never seen one man have so many people pulling for him. They recently had a bike run for him over 100 motorcycles and riders showed up. Ive seen people pray that I would have never thought could pray.

Thank all of you for responding when i just needed comforting words. I pray God continues to comfort snd heal each of you and I pray all these new drugs make it in time to save you all.

Lynn survived 5 gamma knife surgeries for 32 brain mets, ipi was a breeze no problems, zelobraf for 8 month and abaraxene and know on to temador. DONT EVER GIVE UP OR GIVE IN. FIGHT ON MY DEAR FAMILY

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I had a couple moles removed and told I was lucky that it was pre melanoma but the doctor didn't really explain my path report the first time and I had to have them go in deeper until the margins were clear. I was told that I would have to be vigilant and watched closely could anyone explain to me the path reports?

A. Microscopic examination of the slides show an atypical melanocytic lesion with melanocytes in the epidermis and dermis consistent with a dysplastic junctional nevus. The margins of excision cannot be accessed with certainty.

B. Microscopic examination of the slides show a limited specimen showing atypical proliferation of melanocytes in the dermis with junctional component highly consistent with a junctional dysplastic nevus. Recommended reexcision with negative margins

Final Diagnosis
A. Consistent with a dysplastic junctional nevus The margins cannot be accessed with certainty. Therefore, I recommend re excision with negative margins.

B. dysplastic junctional nevus with positive margins Recommend re excision with negative margins

Here is the path report from re excisions

Sections consist of skin erosion, squamous hyperplasia, edema and mild chronic inflammation. Residual carcinoma or dysplasia is not identified in these sections. The margins are free of dysplasia/carcinoma.

Final Diagnosis
Residual dysplasia is not identified. Erosion, squamous hyperplasia, and mild chronic inflammation.

Can anyone kind of explain to me what all this means in a more understanding way? I am having to see a dermatologist about more suspicious moles that are changing and suspicious on other parts of the body. The two biopsies before from the same leg.

Login or register to post replies.

I had a couple moles removed and told I was lucky that it was pre melanoma but the doctor didn't really explain my path report the first time and I had to have them go in deeper until the margins were clear. I was told that I would have to be vigilant and watched closely could anyone explain to me the path reports?

A. Microscopic examination of the slides show an atypical melanocytic lesion with melanocytes in the epidermis and dermis consistent with a dysplastic junctional nevus. The margins of excision cannot be accessed with certainty.

B. Microscopic examination of the slides show a limited specimen showing atypical proliferation of melanocytes in the dermis with junctional component highly consistent with a junctional dysplastic nevus. Recommended reexcision with negative margins

Final Diagnosis
A. Consistent with a dysplastic junctional nevus The margins cannot be accessed with certainty. Therefore, I recommend re excision with negative margins.

B. dysplastic junctional nevus with positive margins Recommend re excision with negative margins

Here is the path report from re excisions

Sections consist of skin erosion, squamous hyperplasia, edema and mild chronic inflammation. Residual carcinoma or dysplasia is not identified in these sections. The margins are free of dysplasia/carcinoma.

Final Diagnosis
Residual dysplasia is not identified. Erosion, squamous hyperplasia, and mild chronic inflammation.

Can anyone kind of explain to me what all this means in a more understanding way? I am having to see a dermatologist about more suspicious moles that are changing and suspicious on other parts of the body. The two biopsies before from the same leg.

Login or register to post replies.

bikerwifee's picture
Replies 0

I dont know how but Lynn ldh went down to 900 was 1300. The dr will not be doing the sixth gamma knife. Lynn is to weak. He starts Temador tomo but they gave us only a 15 to 20 percent chance in it working. Theres just nothing else for us to try. Lynn is a fighter and was willing to try this.

Lynn got saved a long time ago and hes says he knows hes going to heaven. I think hes ready but not ready he prayed today and asked God to heal him hes asked God to please take him home if he wasnt going to heal him. Ive never seen one man have so many people pulling for him. They recently had a bike run for him over 100 motorcycles and riders showed up. Ive seen people pray that I would have never thought could pray.

Thank all of you for responding when i just needed comforting words. I pray God continues to comfort snd heal each of you and I pray all these new drugs make it in time to save you all.

Lynn survived 5 gamma knife surgeries for 32 brain mets, ipi was a breeze no problems, zelobraf for 8 month and abaraxene and know on to temador. DONT EVER GIVE UP OR GIVE IN. FIGHT ON MY DEAR FAMILY

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BrianP's picture
Replies 33
Last reply 5/22/2013 - 9:34pm
Replies by: BrianP, POW, Linny, Tina D, Janet Lee, Randy437, Anonymous, jmmm, Sherron, buffcody

Quick background: 2006 .91mm skin mel excised from left chest area; Sep 2011 dx of stage IIIB, axilla disection, 24 nodes removed 2 positive; Nov 2011 local rediation; Dec 2011 begin interferon; Dec 2012 complete interferon; Dec 2012 clear scans (pet and Brain MRI)

I've been feeling a little run down lately so a few weeks ago I ask my Dr to put in lab work for me to check my iron levels.  For most of my life I've had a tendency to be anemic at times.  Blood work comes back as being anemic.  I'm just thinking no big deal, I've been this way my whole life just give me some iron supplements and I'll be on my way.  Dr persuades me to give stool samples to see if there is any other underlying causes to my anemia.  I reluctantly agree and of course all three stool sampes came back as positive for blood.

My two biggest fears now are 1) I could possibly have colon cancer or 2) this is a reoccurance of my melanoma.

My question to the board is if anyone has seen or heard of blood in the stool as a symptom or indication of possible melanoma reoccurance.  I don't recall seeing the stomach or intestines as a location where metasises typically occur.  I know there are many other possible less severe diagnosis but as many of you know it's difficult not to be concerned that the mel has returned anytime you have anything out of the ordinary.

Any advice or comments would be greatly appreciated.

Brian

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Hello all, we had our every three week check and infusion today on the Merk-3475 Anti-Pd-1 trial ( 5th infusion) , scan results that we took three weeks ago were revealed.  All tumors in the body have shrunk, and the small brain met that was stable prior to treatment is still stable.  Left upper lobe lung: was 14x12mm, now 12x10mm, Anterior mediastinal was 44x26mm now 28mmx24mm.  Right upper lobe lung was 38x26mm now 32mmx22mm.  Liver segment II was 21mmx18mm now 20mmx14mm.  And ventral Peritoneal was 20mmx17mm now 18mmx14mm.  We are extatic!  He has regained all his weight lost from his bowel obstruction, and we have gone on bike rides again...He's awake more often that i am!!! haha!  Hoping it continues for a long time!

On a side note Dr. Ribas noted that they are opening a new arm of the trial with 200 more patients.  Will be randomized between 2mg and 10mg and every 2 weeks or every 3 weeks...at UCLA. 

-Amanda-
Girlfriend of Randy, stage 4 no primary.

"Give thanks in all circumstances"

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Sharon's picture
Replies 1
Last reply 5/22/2013 - 7:50pm
Replies by: NYKaren

May 6 my husband had another scan and blood work and all is clear! We thank God again for this wonderful news. He continues to go to the VA every three months for checkups. We are very thankful for their great care!

God, Family, Friends and Dogs ~ it's all that really matters!

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sjl's picture
Replies 4
Last reply 5/22/2013 - 3:52pm

Hi - it's been awhile since I posted.  My husband's situation has very rapidly deteriorated in the last 3 weeks.  The tumors on his neck are huge, his face is distorted, he can't talk or swallow, one eye will not close and initial scans show that the melanoma is most likely now in the liver and lungs.  Further testing has not been done because it doesn't matter with the neck the way it is.  The tumors are pressing on the corotid artery and the jugular vein.  He is on oxygen and a feeding tube.  He's got blood clots in one lung.  Carbo/Taxol quit working, Yervoy failed, a round of Dacarbazine didn't seem to help and he just completed 5 rounds of radiation that seem to have slightly shrunk what we can see.  His situation is so bad that our local doctor didn't want to complete the radiation that was begun while he was hospitalized and under the care of his melanoma specialist two hours away form home.  He was rehospitalized to get the feeding tube under control and they wanted to complete the radiation so it was done.  Now they want to talk to us about a clinical PD1 trial.  What are your thoughts on this?  And who pays for it?  It would be done at the Hillman Cancer Center in Pittsburgh. I'm not sure if I've tracked down the correct trial or not but if I did it's a phase 1 trial.  He's cKit and BRAF negative, NRAS positive.  I want to go to the appointment as fully prepared as I can be so I can ask the right questions and have some idea of what to expect.

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Ranisa's picture
Replies 2
Last reply 5/22/2013 - 3:28pm
Replies by: Ranisa, BrianP

A friend just called and has been diagnosised with Melanoma.  I am only familiar with docs in the midwest.  Can anyone recommend a dermatlogist and oncologist in the Portland OR area that is a Melanoma specialist?  Thanks!

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Here's the archive of today's webinar:  http://www.melanomainternational.org/news/til_nci.html 

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