MPIP: Melanoma Patients Information Page

The MPIP is the oldest and largest community of people affected by melanoma hosted through the Melanoma Research Foundation. It is designed to provide support and information to caregivers, patients, family and friends. Once you have been touched by melanoma—either as a patient or as a family member or friend of a patient—you become part of a community. It is not a community anyone joins willingly. But if you must be part of this group, you will find no better place to find the tools you need in your journey with this cancer, and the friends who can make that journey more bearable.

The information on the bulletin board is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

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BarbieGirl's picture
Replies 7
Last reply 4/20/2012 - 12:14am

I spoke with Allen just a bit ago, and found out his wife, Carol, passed away peacefully on April 14th.  A 'celebration' of her life was held today.  Even though Carol didn't have melanoma, I feel this needed to be posted on the main board.  Allen hung around here for many, many years sharing his knowledge, wisdom, encouragement, hope and grief with so many.  His family is there with him, and he said he's doing okay; just glad that Carol is now pain free in Heaven.  Carol and Allen would have celebrated their 40th wedding anniversary this year;  and she spent many of those years by Allen's side, fighting this beast.  She encouraged him to do what he felt he needed to do, and go where he felt he needed to go, to fight his melanoma.  Allen hasn't posted much here since the bulletin board changed, and his computer crashed, so he lost all his contacts.  If you'd like to contact him, his email address is redneck_77 @ att.net (no spaces).

I've met Allen--he even stayed overnight once in my barbie room! =)  I wanted to meet Carol sooo much, especially when I was in Ft. Lauderdale last summer, but things just didn't work out.  I chatted with her on the phone several times over the last few years.  My heart is breaking right now.  Please keep Allen and the family in your hearts, thoughts and prayers.

I love you, Allen, and I'm so sorry.  There are no words, only tears......

*Hugz* from my heart to yours,

~Lisa~

Life is NOT a journey to the grave with the intention of arriving in an attractive & well-preserved body, but rather to skid in sideways, champagne in one hand, strawberries in the other, body totally used up & worn out, & screaming WOOHOOO, WHAT A RIDE!!

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matthew82wa's picture
Replies 6
Last reply 4/18/2012 - 1:45am

My name is Matthew I live in Leavenworth WA and I am planning on doing a fundraiser this summer to Hike For A Cure I lost a cousin to Melanoma last year Hike For A Cure is what my Foundation is called

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Lisa13's picture
Replies 24
Last reply 4/23/2012 - 6:09pm

Why is this happening??  Why would my brain tumour be growing since I had it done last November and now they say there's nothing they can do. Why can't people by resected or cyberknife!!

Some body help. I'm completely freaking out.

Many impossible things have been accomplished for those who refuse to quit

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Snickers60's picture
Replies 6
Last reply 4/18/2012 - 11:21pm

It's been a LONGGGG time sine my hubby and I have been here.   He has been free of melanoma since Oct. 1999 when he had a melanoma removed from his right ear lobe !   They cut the lobe off - did sentinel node biopsy, which was clean and we went to M. D. Anderson for 8 years.   We were released to our Doc here upon our own request and he has done an excellent job of caring for him.

On Feb. 29th, Wayne (the patient) had his physical - excellent helath - great blood work - cholesterol a little high.  Doc suggested he might want to do Calcium scan because most of his family dropped dead from heart attacks.   On a whim, he did.   The Doc called......told him he had a good bit of plaque, but the problem was no longer that.  There was a Shadow on his left lung and he thought they should see about it pronto.   Long story short - had the needle biopsy and it was MELANOMA !  Headed for M. D. ANDERSON as soon as we could get there after test had been sent yada yada.   Did PET SCAN - BRAIN MRI - Blood.    7 METS !    2 in left lung - 1 in abdomen - 1 on right leg - 1 in spine at L-5 - 1 in liver - and I lost my mind on the 7th one.  I'm pretty crazy right now.  

I don't have to tell you what we're going through.   We will go back to M. D. on Monday to see Doc one more time, and start ZELBRAF !   The Brain MRI was clean so because of that they decided not to do Bio-chem which was the original plan.    We're happy about that........I THINK !

I am his wife - NANCY !    Hi NANCY !    HEY YA'LL !   And we are trying to breathe !!!!!!!   Scared............but trying to TRUST GOD and not walk in FEAR ! 

I (Nancy) especially need to talk.   I'm coming undone, because guess what, I've already been shut in and shut down sick with Fibro and you name it for the last 30 years, and how can we possibly go through this with no one well.  We have a fantastic marriage........the kind folks dream about.   The NOTEBOOK Kind.......so close.........too close and not much family.   Only son is in Charlotte about 12 hours away struggling to live after losing his job in the recession.  

I feel like I am drowning....................he has taken care of me all these years.   Sometimes I'm too weak to even carry my purse and he does that too.  Have only gotten myself to Walmart one exit down about 5 times in the last year.   Was off the operating table only 2 weeks when we learned this.  Have liver disease (but not cancer) had a nasty gallbladder removed and all that on top of a dozen other things like the Fibro and CFS and several bad injuries from a wreck and 2 falls.   HOW WILL WE DO THIS.............

WHAT WAS GOD THINKING......................

I welcome any an all input and apologize for the long post right out of the shute !!!   

Matt. 15:13 "Every plant that my Heavenly Father hath not planted shall be pulled up by the roots". "With God all things are possible" ! Keep the FAITH !

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Anonymous's picture
Anonymous
Replies 1
Last reply 4/17/2012 - 11:49pm
Replies by: Swanee

Hi, 

 

Does anyone know how Kevin is diong on Zelboraf?

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Anonymous's picture
Replies 2
Last reply 4/17/2012 - 1:23pm
Replies by: JerryfromFauq, Phil S

My beautiful, wonderful Mother, age 60 was diagnosed last Thursday with anal melanoma.  I am looking for any advise on the most experienced doctors or clinics with this kind of melanoma.  We live live in Calgary, Canada and I am certain that doctors here do not have any experience in anal melanoma.  I need the very best treatment for my Mom, I will and can travel anywhere.  She will have her PET scan on Friday.  Please help us if you have any information on doctors and clinincs.  Thank you.

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natasha's picture
Replies 3
Last reply 4/18/2012 - 12:09am
Replies by: imissmommy2003, SarahS

Hello everyone !

Today I had my first sheduled follow up appointment with Doctors in Adenbrooks hospital Cambridge .

Doctor checked my all body (but it took about 2 minutes for her ) and said all moles look fine.I am a bit suprised full body check is so quick .

I had question about pregnancy and I was told I can go ahead with what ( but I am not sure myself and very scared).

I was told 0.2mm radial growth melanoma gives me very good chanse to survive and have children:)

Doctor checked my lymthnodes as well and my Wide excision scar .

So far so good !!!!!!!

Natasha , 31 Years old lady from UK

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MeNDave's picture
Replies 11
Last reply 4/20/2012 - 12:36pm

Well, we've had a heck of a week.  Dave and I visited with the trial nurse for the MDX-1105 last Wednesday, and they requested a brain MRI prior to starting.  A lumbar spine MRI indicated a bulging disk which is causing Dave's back pain (done on Tuesday), but also diffuse bone mets to the spine.  On Wednesday we travelled to UPMCs Hillman Cancer Center for the MK-3475 trial, but the only seat left is for post IPI patients.  Back to Roswell Friday, and an upper spine MRI showed additional diffuse mets to the upper spine, and brain MRI today showed 6 small (all less than a centimeter) lesions on the brain.  So next up is gamma knife on Wednesday, and then he will start IPI Tuesday (hopefully).

I sometimes want to ask if they are reading HIS scan results, as after all this transpired today, Dave went back to work - he even amazed the neurosurgeon...

Any advice on gamma knife is much appreciated - he plans on going to work on Thursday.  He amazes me.

All my best to all you,

Maria

Don't ever, EVER, give up!

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rmuffybear's picture
Replies 8
Last reply 4/17/2012 - 12:41am

This web site has been so helpful.  I had two melanoma surgeries, 5 lymph nodes were taken from the groin.  Melanoma Stage 3.  My foot and ankle are swollen.  I was told to wear the compression stockings all day so I have for 10 days. I had two leg messages from a therapist.  Now my ankle has a rash.  Is this a problem?  Will the swelling go down?  Thank you to all of you who have helped me get this far.

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dstu5785's picture
Replies 11
Last reply 4/25/2012 - 11:48am

Hi,

My wife is Stage IV diagnosed on 12/5/2011 and since then has done Whole Brain Radiation, Gamma Knife in Feb and has been on Zelboraf since Jan. of this year. She originally had 4 brain mets of various sizes. About a 1 1/2 weeks ago she suddenly lost ability to walk and use her left arm. Doctors did Brain MRI and said that brain mets have started to increase along with multiple new mets. Today, I found out that blood work from Friday showed LDH level back to elevated levels (1700) so assume Zelboraf stopped working. The nurses and doctors are recommending keeping her as comfortable as possible (Hospice) and are saying nothing really left to be done.

Any recommendations on anything further I could persue for her no matter how small the odds are? We just don't want to accept that nothing else can be done. She's 42 and we have 4 kids. Don't want to give up on her.... 

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Bonnets's picture
Replies 11
Last reply 4/25/2012 - 2:01pm

WIth my hubby having surgerey for tumor removal on Friday, with Sentinal node biopsy, I'm thinking ahead. If the tumor cells have spread to the noded we will be looking  for melanoma specialist. Since we are in the Hudson Valley I am thinking SKM. Is there more than 1 specialist there? Is there anyplace else in the NY, CT area we shud consider? Jean

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Lisa13's picture
Replies 6
Last reply 4/16/2012 - 9:58pm
Replies by: jag, kylez, Lisa13, Anonymous, Kathy of Massachusetts

What if someone had a tumour last November and some of it seems a bit bigger.  They thing it's mostly dead tissues, but now they're double checking with their group of people.  What happens if it's growing and a tumour that can't ben gamma knifed, what are the other options?  What if cranitomoy isn't a possibility? 

I have 4th infusion of ipi (on my reinduction) so I'm hoping the reasing it could be gettign bigger is because of ip.

Lisa

Many impossible things have been accomplished for those who refuse to quit

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deardad's picture
Replies 6
Last reply 4/19/2012 - 6:43pm

Hi everyone, saw dad's oncologist tonight and it was confirmed that a new lesion has appeared in the sub fat after 7 months on Zelboraf. Lesion was excised and disease at this point is stable in liver with slight growth in existing tumors. Hasn't had a MRI yet though.

Next move to get him on the BRAF MEK combo by Roche if MRI is clear and there is a place for him.

Hoping the MEK will have an effect in time for an ANTIPD1 trial in Australia.

What a stressful time, I'm really feeling for everyone going this.

Nahmi from Melbourne

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rbruce's picture
Replies 13
Last reply 5/21/2012 - 5:59pm
Replies by: Anonymous, TracyR, WendyR3, keesvp, Bubbles, melmar, audgator, LynnLuc

Please list which trial you're on, date started, and where and next scans, plus any wise effect or results info you want to share.  Lots of us are on this and some of the 12 week scans are showing great results.  

Robert B. started March 15, UCSF, scans June 5. Just had 3rd infusion, some bone and muscle ache and slight rash.  Not a problem.

The circumstances of our lives have as much power as we choose to give them. David McNally

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dezb's picture
Replies 5
Last reply 4/17/2012 - 1:14am
Replies by: LynnLuc, Erinmay22, Anonymous, dezb

Cancer Breakthrough with Spontaneous Remission

by Jeffrey Dach MD

Injecting cancer into mice is a major activity at Wake Forest Medical School in North Carolina, keeping students busy with many publications over the years.  Injecting the cancer cells prompty kills the mouse, but first, the mouse makes fluid in the abdomen, also called ascites. 

Left Image: Lab Mice courtesy of wikimedia commons.

Chance Favors the Prepared Mind - Luis Pasteur

Then one day, a medical student injected a mouse and noticed something strange happened. What happened? Nothing.  The mouse didn't get cancer, and no fluid in the abdomen.  The first mouse that could kill cancer was discovered.

Spontaneous Regression of Cancer in the Mouse

Once identified as a "cancer killing" mouse, the little furry fellow was earmarked for study.  These were exciting times in the lab.  Researchers in the lab asked some urgent questions. Why didn't this mouse get cancer and ascites like all the others?  How was this mouse able to resist injected cancer cells? What was the mechanism for the rejection of the cancer cells?

Over the next 3 years, research studies showed these mice are immune to cancer, a trait innate to this SR/CR strain.  Their immunity to cancer was genetically determined.  These mice have an immune system that could fight cancer by sending immune cells, the leukocytes to attack and kill the cancer cells, just as any other microbial invader. These mice were dubbed SR/CR mice for Spontaneous Regression/Complete Resistant (to Cancer).(2)

Saving All the Other Mice From Cancer

What about the other normal mice? They had no immunity and promptly died of cancer.
Could these normal mice be saved by infusing the white cells, the lymphocytes,  from the SR/CR mice ?  More experiments quickly confirmed this was true, cancer resistance could be transferred to normal mice transfused with white blood cells from SR/CR mice.(3)  In addition, the protective SR/CR white cells could be stockpiled in cold storage, infused weeks later, and still retain activity.(4)

Human Mice - Spontaneous Regression of Cancer

What about us humans?  Do we have a similar immunity to cancer, with some humans able to resist cancer?  Yes, and this is called spontaneous regression  (remission) of cancer, which has been reported for virtually all cancers many times in the medical literature.  Spontaneous regression can be seen most commonly in neuroblastoma, renal cell carcinoma, malignant melanoma and lymphomas/leukemias (see Papac RJ and Chodorowski Z)(5)(6)

Sir William Osler, a legendary doctor reported 14 cases of breast cancer spontaneous remission.   I have seen a documented case of spontaneous regression of breast cancer.(8)  A study by Dr Gilbert Welch concluded that small breast cancers may spontaneously regress.  Gina Kolata wrote a New York Times piece about it.  

Adoptive Immunotherapy - A Promising New Cancer Treatment

The mouse model showed cancer resistance can be tranferred by white blood cells called T lymphocytes.  How about humans?  Steven A Rosenberg MD PhD has work in humans showing great promise.  As Chief of Surgery at the National Cancer Institute, Dr. Rosenberg has developed a cancer treatment using immunotherapy with T lymphocytes  infused into cancer patients.  His results have been remarkable.(7)  Dr Rosenberg's treatment uses a cancer patient’s own T lymphocytes which have innate anti-tumor activity, the lymphocytes are activated and cloned in a test tube, and then reinfused into the cancer patient.  This method is currently the most effective treatment for patients with metastatic melanoma producing tumor regressions in 50% of patients. See Rosenberg's case images below showing tumor regression (7).

Figure 2 from article: Examples of objective tumor regressions in patients receiving adoptive cell transfer of autologous anti-tumor lymphocytes following a lymphodepleting preparative regimen In each case the pretreatment scans and photos are shown on the left and the post-treatment on the right.

Left panel (a) A 45-year-old male with metastatic melanoma to the liver (upper) and right adrenal gland (middle) who was refractory to prior treatment with high dose α interferon as well as high-dose interleukin 2 (IL2). He underwent a rapid regression of metastases and developed vitiligo (lower).

Right panel (b) A 55-year-old male with rapid tumour growth in the axilla as well as multiple brain metastases from metastatic melanoma that was refractory to prior treatment with high dose IL2 who underwent rapid regression of nodal and brain metastases.

What's in the Future?

Since Adoptive cell transfer is not a drug, and competes with conventional drug treatment (chemotherapy), the pharmaceutical industry might be hostile to the idea.
T Cell Immune therapy is highly personalized treatment, labour-intensive and requires laboratory expertise.  Each lymphocyte preparation is uniquely created for each patient and this makes it difficult to commercialize.   Where to get the anti-tumor T cells?  Blood banks have been providing stem cells for clinical studies, and might also serve as a source for anti-tumour T cells.

Driving Through the Rear View Mirror - Fever Therapy

One of the curious things about spontaneous regression of cancer is its association with high fever from bacterial infection such as erysipales.  This was reported by surgeons many years ago when they observed that some cancer patients had a remarkable  regression of the tumor mass if their clinical course was complicated by post-operative infection of some type leading to high fever and chills.  If the infection didn't kill them, these cancer patients did well, with a remarkable remission from their cancer.

One such emminent sugeon was Chief of Bone Surgery at the Memorial Sloan Kettering Hospital.  His name was William Coley, and he perfected this treatment of injecting bacterial toxins (Coley's Toxins) into cancer patients inducing high fever, stimulating the immune system and obtaining remarkable regression in many inoperable cases. After a long and successful period of use, Coley died , and his Coley's Toxin treatment was banished from Memorial in 1955.  In 1963, the Food and Drug Administration (FDA) refused to “grandfather” Coley’s toxins, as a pre-existing medicine, making it illegal in the US.

Coley's toxins probably activated the immune system to send immune cells called  T lymphocytes to the tumor and kill it.  Perhaps Dr Steven Rosenberg can look through the rear view mirror, and the example of Coley's toxins,  and drive the NIH into the next century with a cure for cancer. 

Is this the end of cancer? I hope so.

Links and References

(1) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164507/
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6682–6687.
Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice. Zheng Cui, Mark C. Willingham, Amy M. Hicks, Martha A. Alexander-Miller et al.

We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden, and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately after exposure, cancer cells provoke a massive infiltration of host leukocytes, which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance, which may have potential for therapy or prevention of cancer. 

(2) http://www.cancerimmunity.org/v6p11/060911.htm
Cancer Immunity, Vol. 6, p. 11 (31 October 2006) Submitted: 28 March 2006. Resubmitted: 17 July 2006. Accepted: 28 September 2006. Effector mechanisms of the anti-cancer immune responses of macrophages in SR/CR mice.

Amy M. Hicks et al. The killing of cancer cells in SR/CR mice requires three distinct phases. First, the leukocytes must migrate to the site of cancer cells after sensing their presence. Second, they must recognize the unique properties of the cancer cell surface and make tight contact with it. Third, the effector mechanisms must finally be delivered to target cells. The difference between SR/CR and WT mice seems to lie in one of the first two phases. Upon challenge with cancer cells, WT mice lack leukocyte infiltration and rosette formation. Apparently, the mutation in SR/CR mice renders the leukocytes capable of sensing unique diffusible and surface signals from cancer cells, and of responding to the activation signals by migration and physical contact. Once the first two phases are accomplished, unleashing the pre-existing effector mechanisms for killing seems to ensue by default. Therefore, the mutated gene (or genes) likely determines whether leukocytes interpret the signals from cancer cells as inhibition, as in WT leukocytes, or as activation of migration and target recognition, as in SR/CR leukocytes. Identifying the mutated gene (or genes) will likely explain this unique resistance to cancer through immunity.

(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458507/?tool=pubmed
Proc Natl Acad Sci U S A. 2006 May 16; 103(20): 7753–7758.  Immunology Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Amy M. Hicks et al.

(4) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749872/?tool=pubmed
BMC Cancer. 2009; 9: 328. Impact of sex, MHC, and age of recipients on the therapeutic effect of transferred leukocytes from cancer-resistant SR/CR mice
John R Stehle, Jr,1 Michael J Blanks,2 Gregory Riedlinger,1,3 Jung W Kim-Shapiro,1 Anne M Sanders,1 Jonathan M Adams,1 Mark C Willingham,1 and Zheng Cui1
1Department of Pathology, Wake Forest University School of Medicine Winston-Salem, North Carolina 27157, USA

Abstract Background
Spontaneous Regression/Complete Resistant (SR/CR) mice are resistant to cancer through a mechanism that is mediated entirely by leukocytes of innate immunity. Transfer of leukocytes from SR/CR mice can confer cancer resistance in wild-type (WT) recipients in both preventative and therapeutic settings. In the current studies, we investigated factors that may impact the efficacy and functionality of SR/CR donor leukocytes in recipients.

Spontaneous regression of cancer in Humans

(5)http://www.ncbi.nlm.nih.gov/pubmed/9891219
In Vivo. 1998 Nov-Dec;12(6):571-8.
Spontaneous regression of cancer: possible mechanisms. Papac RJ.
Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA.

Spontaneous regression of cancer is reported in virtually all types of human cancer, although the greatest number of cases are reported in patients with neuroblastoma, renal cell carcinoma, malignant melanoma and lymhomas/leukemias. Study of patients with these diseases has provided most of the data regarding mechanisms of spontaneous regression. Mechanisms proposed for spontaneous regression of human cancer include: immune mediation, tumor inhibition by growth factors and/or cytokines, induction of differentiation, hormonal mediation, elimination of a carcinogen, tumor necrosis and/or angiogenesis inhibition, psychologic factors, apoptosis and epigenetic mechanisms. Clinical observations and laboratory studies support these concepts to a variable extent. The induction of spontaneous regression may involve multiple mechanisms in some cases although the end result is likely to be either differentiation or cell death. Elucidation of the process of spontaneous regression offers the possibility of improved methods of treating and preventing cancer.

(6) http://www.ncbi.nlm.nih.gov/pubmed/17724923
Przegl Lek. 2007;64(4-5):380-2.
[Spontaneous regression of cancer--review of cases from 1988 to 2006]
Chodorowski Z, Anand JS, Wiśniewski M, Madaliński M, Wierzba K, Wiśniewski J.
Katedra i Klinika Chorób Wewnetrznych, Geriatrii i Toksykologii Klinicznej, Akademii Medycznej w Gdańsku.

Spontaneous regression of malignant tumours is a rare and enigmatic phenomenon. We reviewed the cases of spontaneous regression of cancer in medical literature according to MEDLINE database in the period 1988-2006 and compared them with similar reviews from 1900-1987 period. The number of reported cases of spontaneous regression increased steadily in XX century, probably due to a rising interest in this problem and new possibilities of radiological and biopsy examinations. Spontaneous regression of malignancy was reported in almost all types of human cancer, although the greatest number of cases in years 1988-2006 were reported in patients with nephroblastoma, renal cell carcinoma, malignant melanoma, lymphoma. Elucidation of the process of spontaneous regression offers the possibility of improved methods of preventing andlor treating cancer.

Adoptive Cell Therapy ACT

(7) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553205/?tool=pubmed
Nat Rev Cancer. 2008 April; 8(4): 299–308.
Adoptive cell transfer: a clinical path to effective cancer immunotherapy
Steven A. Rosenberg, Nicholas P. Restifo, James C. Yang, Richard A. Morgan, and Mark E. Dudley. Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged as the most effective treatment for patients with metastatic melanoma and can mediate objective cancer regression in approximately 50% of patients. The use of donor lymphocytes for ACT is an effective treatment for immunosuppressed patients who develop post-transplant lymphomas. The ability to genetically engineer human lymphocytes and use them to mediate cancer regression in patients, which has recently been demonstrated, has opened possibilities for the extension of ACT immunotherapy to patients with a wide variety of cancer types and is a promising new approach to cancer treatment.

Figure 2
Examples of objective tumour regressions in patients receiving adoptive cell transfer of autologous anti-tumour lymphocytes following a lymphodepleting preparative regimen
In each case the pretreatment scans and photos are shown on the left and the post-treatment on the right. a | A 45-year-old male with metastatic melanoma to the liver (upper) and right adrenal gland (middle) who was refractory to prior treatment with high dose α interferon as well as high-dose interleukin 2 (IL2). He underwent a rapid regression of metastases and developed vitiligo (lower). b | A 55-year-old male with rapid tumour growth in the axilla as well as multiple brain metastases from metastatic melanoma that was refractory to prior treatment with high dose IL2 who underwent rapid regression of nodal and brain metastases.

The future of ACT

In contrast to common epithelial cancers, melanoma appears to be a tumour that naturally gives rise to anti-tumour T cells. However, other cancers are equally susceptible as the targets of reactive T cells. The susceptibility of melanoma to ACT provides optimism for the application of ACT to common epithelial cancers using TCR gene-modified lymphocytes.

A major problem with the application of ACT is that it is a highly personalized treatment and does not easily fit into current modes of oncological practice. The treatment is labour-intensive and requires laboratory expertise. In essence, a new reagent is created for each patient and this patient-specific nature of the treatment makes it difficult to commercialize. Pharmaceutical and biotechnology companies seek off-the-shelf drugs, easy to produce, vial and administer. From a regulatory standpoint, ACT might be more appropriately delivered as a service rather than as a ‘drug’. Blood banks have been instrumental in providing CD34+ haematopoietic stem cells for clinical studies and might be the ideal location for the generation of the anti-tumour T cells needed for ACT.

As modern science increasingly provides the physician with sophisticated information about the unique aspects of an individual cancer, changes in the modes of care delivery need to accommodate this. The ability to use this patient-specific information can lead to a new era of personalized medicine in which individual treatments, such as ACT, are devised for each patient.Studies of ACT have clearly demonstrated that the administration of highly avid anti-tumour T cells directed against a suitable target can mediate the regression of large, vascularized, metastatic cancers in humans and provide guiding principles as well as encouragement for the further development of immunotherapy for the treatment of patients with cancer.

(8)The Medical Aspects of Carcinoma of the Breast, with a Note on the Spontaneous Disappearance of Secondary Growths, OSLER W., American Medicine: April 6 1901; 17-19; 63-66. 

Coley's Toxins Fever Therapy

http://www.ralphmoss.com/html/coley.pdf
THE TREATMENT OF CANCER WITH COLEY’S TOXINS

http://bioinfo.tg.fh-giessen.de/cancer/hobohm-2005-bjc.pdf
British Journal of Cancer (2005) 92, 421 – 425 Fever therapy revisited
U Hobohm*,1 1University of Applied Sciences, Bioinformatics, Wiesenstrasse 14, D-35390 Giessen, Germany

http://findarticles.com/p/articles/mi_m0ISW/is_251/ai_n6112670/?tag=cont...
Coley's Toxins—The First Century Townsend Letter for Doctors and Patients, June, 2004 by Helen Coley Nauts

Jeffrey Dach MD
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I can not take responsibility for any breaches of confidentiality that may occur.

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